Advances in Immune Monitoring Approaches for Sepsis-Induced Immunosuppression.
Advances in Immune Monitoring Approaches for Sepsis-Induced Immunosuppression.
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脓毒症引起的免疫抑制的免疫监测方法的进展
DOI：
10.3389/fimmu.2022.891024
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发表时间：
2022
影响因子：
7.3
通讯作者：
中科院分区：
文献类型：
--
作者：
脓毒症代表由于异常宿主反应而导致的危及生命的器官功能障碍。值得注意的是，大多数患者在脓毒症期间和之后经历了严重的免疫抑制，这与医院感染的发生和院内死亡的较高风险显著相关。然而，脓毒症引起的免疫麻痹的临床体征仍然高度不可检测和模糊。鉴于此，用于监测脓毒症患者的免疫功能状态的特异性但稳健的生物标志物在临床实践中具有突出意义。反过来，具有免疫抑制状态的脓毒症患者亚组的分层将极大地有助于个性化辅助免疫治疗的实施。在这篇综述中，我们全面总结了脓毒症相关的免疫抑制在细胞水平上的机制，并强调了针对先天性和适应性免疫反应的功能状态的免疫监测方法的最新进展。
Sepsis represents a life-threatening organ dysfunction due to an aberrant host response. Of note is that majority of patients have experienced a severe immune depression during and after sepsis, which is significantly correlated with the occurrence of nosocomial infection and higher risk of in-hospital death. Nevertheless, the clinical sign of sepsis-induced immune paralysis remains highly indetectable and ambiguous. Given that, specific yet robust biomarkers for monitoring the immune functional status of septic patients are of prominent significance in clinical practice. In turn, the stratification of a subgroup of septic patients with an immunosuppressive state will greatly contribute to the implementation of personalized adjuvant immunotherapy. In this review, we comprehensively summarize the mechanism of sepsis-associated immunosuppression at the cellular level and highlight the recent advances in immune monitoring approaches targeting the functional status of both innate and adaptive immune responses.
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影响因子：
1.3
作者：
Danahy DB;Strother RK;Badovinac VP;Griffith TS
通讯作者：
Griffith TS
影响因子：
7.3
作者：
Bouras M;Asehnoune K;Roquilly A
通讯作者：
Roquilly A
DOI：
10.4049/jimmunol.1700375
发表时间：
2017-09-15
期刊：
Journal of immunology (Baltimore, Md. : 1950)
影响因子：
--
作者：
Chen CW;Mittal R;Klingensmith NJ;Burd EM;Terhorst C;Martin GS;Coopersmith CM;Ford ML
通讯作者：
Ford ML
影响因子：
120.7
作者：
Boomer, Jonathan S.;To, Kathleen;Chang, Kathy C.;Takasu, Osamu;Osborne, Dale F.;Walton, Andrew H.;Bricker, Traci L.;Jarman, Stephen D., II;Kreisel, Daniel;Krupnick, Alexander S.;Srivastava, Anil;Swanson, Paul E.;Green, Jonathan M.;Hotchkiss, Richard S.
通讯作者：
Hotchkiss, Richard S.
影响因子：
5.5
作者：
Andre, Maya C.;Gille, Christian;Orlikowsky, Thorsten W.
通讯作者：
Orlikowsky, Thorsten W.