Analogous Recognition of Phospholipids by Insect Phagocytes and Mammalian Macrophages
Analogous Recognition of Phospholipids by Insect Phagocytes and Mammalian Macrophages
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昆虫吞噬细胞和哺乳动物巨噬细胞对磷脂的类似识别
DOI：
10.3181/00379727-182-42339
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发表时间：
1986
影响因子：
--
通讯作者：
I. Fidler
中科院分区：
文献类型：
--
作者：
S. Ratner;A. Schroit;S. Vinson;I. Fidler
摘要从蛾Heliothis virescens幼虫和小鼠腹腔巨噬细胞的吞噬细胞被观察到优先结合带负电荷的磷脂囊泡含有磷脂酰甘油或磷脂酰丝氨酸相比，中性或带正电荷的囊泡。由于吞噬细胞在整个进化过程中保留了其内吞作用的原始功能，因此带负电荷的磷脂的识别可能是巨噬细胞识别潜在靶点的原始机制。
Abstract Phagocytic cells from larvae of the moth Heliothis virescens and peritoneal macrophages of mice were observed to preferentially bind negatively charged phospholipid vesicles containing phosphatidylglycerol or phosphatidylserine as compared to neutral or positively charged vesicles. Since phagocytes have retained their primitive function of endocytosis throughout evolution, the recognition of negatively charged phospholipids may be a primitive mechanism for the identification of potential targets by macrophages.
将荧光磷脂酰丝氨酸插入红细胞的质膜中。
DOI：
--
发表时间：
1983
期刊：
The Journal of biological chemistry
影响因子：
--
作者：
Tanaka,Y;Schroit,AJ
通讯作者：
Schroit,AJ