Actin and Actin-Binding Proteins: Masters of Dendritic Spine Formation, Morphology, and Function.
Actin and Actin-Binding Proteins: Masters of Dendritic Spine Formation, Morphology, and Function.
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DOI：
10.2174/1874082000903020054
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发表时间：
2009-01-01
期刊：
影响因子：
--
通讯作者：
Webb DJ
中科院分区：
文献类型：
--
作者：
Lin WH;Webb DJ
树突棘是富含肌动蛋白的突起，其包括突触的突触后位点，并且在中枢神经系统中接收大多数兴奋性突触输入。这些结构是认知过程的核心，其数量、大小和形态的改变与许多神经系统疾病有关。虽然肌动蛋白细胞骨架被认为是支配棘的形成，形态和突触功能，我们才刚刚开始了解肌动蛋白结合蛋白（ABP）的肌动蛋白重组的调制如何有助于树突棘和突触的功能。在这篇综述中，我们讨论了目前已知的ABPs在调节树突棘和突触的形成，形态，运动性和可塑性的作用。
Dendritic spines are actin-rich protrusions that comprise the postsynaptic sites of synapses and receive the majority of excitatory synaptic inputs in the central nervous system. These structures are central to cognitive processes, and alterations in their number, size, and morphology are associated with many neurological disorders. Although the actin cytoskeleton is thought to govern spine formation, morphology, and synaptic functions, we are only beginning to understand how modulation of actin reorganization by actin-binding proteins (ABPs) contributes to the function of dendritic spines and synapses. In this review, we discuss what is currently known about the role of ABPs in regulating the formation, morphology, motility, and plasticity of dendritic spines and synapses.