Expression of human T cell immunoglobulin domain and mucin-3 (TIM-3) on kidney tissue from systemic lupus erythematosus (SLE) patients
Expression of human T cell immunoglobulin domain and mucin-3 (TIM-3) on kidney tissue from systemic lupus erythematosus (SLE) patients
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DOI：
10.1007/s10238-013-0264-3
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发表时间：
2014-11-01
影响因子：
4.6
通讯作者：
Peng, Tao
中科院分区：
文献类型：
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作者：
Guo, Ling;Yang, Xiangdong;Peng, Tao
本研究的目的是检测系统性红斑狼疮(SLE)患者和非系统性红斑狼疮(SLE)患者肾组织中TIM-3的表达，并比较两者之间的差异。将272例SLE患者作为SLE组，62例非SLE患者作为对照组。系统性红斑狼疮患者接受经皮肾活检。我们检测了所有入选病例的肾组织中TIM-3的表达和血清中的血清学参数。比较不同组间TIM-3的表达及血清学指标。TIM-3蛋白阳性率在SLE组为97.1%(264/272)，而非SLE组为95.2%(59/62)，对照组仅3/62例阳性。反映SLE活动性的几乎所有血清学指标在两组间均有显着性差异。TIM-3的表达程度与病理表现呈正相关。TIM-3的高免疫反应性与血清学分级显著相关(P
The aim of this study was to evaluate the expression of TIM-3 in renal tissue from patients with systemic lupus erythematosus (SLE) and patients without SLE, and to evaluate the difference of TIM-3 expression between them. A total of 272 patients with SLE as SLE group and 62 patients without SLE as control group were enrolled in the present study. Patients with SLE accepted percutaneous renal biopsy. We examined the expression of TIM-3 in renal tissue and the serological parameters in serum from all enrolled cases. The expression of TIM-3 and serological parameters were compared between the different groups. Positive staining of TIM-3 protein was seen in 97.1 % patients with SLE (264 out of 272), but 95.2 % negative staining in the cases without SLE (59 out of 62), only 3 out of 62 patients in control group were positive staining of TIM-3. There were significant differences between two groups in almost all serological markers which reflect SLE activity. There was a nearly positive correlation between pathological manifestations and expression degree of TIM-3. High immuno-reactivity of TIM-3 was found to be significantly correlated with serological grade (p