Frontal and posterior cingulate metabolic impairment in the behavioral variant of frontotemporal dementia with impaired autonoetic consciousness
Frontal and posterior cingulate metabolic impairment in the behavioral variant of frontotemporal dementia with impaired autonoetic consciousness
复制标题
DOI：
10.1002/hbm.21282
复制
发表时间：
2012-06-01
影响因子：
4.8
通讯作者：
Salmon, Eric
中科院分区：
文献类型：
--
作者：
Bastin, Christine;Feyers, Dorothee;Salmon, Eric
虽然记忆功能障碍不是额颞叶痴呆（bv-FTD）行为变体的显著特征，但有证据表明这些患者存在特定的情景记忆缺陷。他们也有问题，监测他们的内存性能。本研究的目的是探讨有意识地检索自己的编码的事件（自主意识）的能力，并监测记忆性能的感知知道（FOK）的bv-FTD。患者脑代谢（FDG-PET）分析允许检查bv-FTD中情节记忆受损是否与病理学特征性额叶功能障碍或与Papez回路相关的记忆特异性区域功能障碍相关。数据来自8例bv-FTD患者和26例健康对照。在FOK实验的再认记忆阶段，用Remember反应评价自主意识。作为一个组，bv-FTD患者表现出自主意识和FOK准确性在偶然水平上下降。虽然大多数（7例）患者的记忆监测受损，但4例bv-FTD受试者存在个体自主意识受损。他们特别显示，前内侧前额叶皮层、左背外侧前额叶皮层（靠近上级额沟）、顶叶区域和后扣带皮层的代谢减少。通过考虑代谢受损脑区在自我参照过程中的作用，对这些发现进行了初步解释，表明bv-FTD患者有意识地检索情景记忆的问题可能至少部分源于对自我信息的获取和维护/使用不足。额颞叶痴呆伴自主意识受损的行为变体中的额叶和后扣带回代谢障碍（Brain Mapp，2011）。(c)2011 Wiley-Liss，Inc.
Although memory dysfunction is not a prominent feature of the behavioral variant of frontotemporal dementia (bv-FTD), there is evidence of specific deficits of episodic memory in these patients. They also have problems monitoring their memory performance. The objective of the present study was to explore the ability to consciously retrieve own encoding of the context of events (autonoetic consciousness) and the ability to monitor memory performance using feeling-of-knowing (FOK) in bv-FTD. Analyses of the patients' cerebral metabolism (FDG-PET) allowed an examination of whether impaired episodic memory in bv-FTD is associated with the frontal dysfunction characteristic of the pathology or a dysfunction of memory-specific regions pertaining to Papez's circuit. Data were obtained from eight bv-FTD patients and 26 healthy controls. Autonoetic consciousness was evaluated by Remember responses during the recognition memory phase of the FOK experiment. As a group, bv-FTD patients demonstrated a decline in autonoetic consciousness and FOK accuracy at the chance level. While memory monitoring was impaired in most (seven) patients, four bv-FTD participants had individual impairment of autonoetic consciousness. They specifically showed reduced metabolism in the anterior medial prefrontal cortex, the left dorsolateral prefrontal cortex (near the superior frontal sulcus), parietal regions, and the posterior cingulate cortex. These findings were tentatively interpreted by considering the role of the metabolically impaired brain regions in self-referential processes, suggesting that the bv-FTD patients' problem consciously retrieving episodic memories may stem at least partly from deficient access to and maintenance/use of information about the self. Frontal and posterior cingulate metabolic impairment in the behavioral variant of frontotemporal dementia with impaired autonoetic consciousness Hum Brain Mapp, 2011. (c) 2011 Wiley-Liss, Inc.