Ascorbic acid in aqueous humor and serum of patients with and without cataract; physiologic significance of relative concentrations.
Ascorbic acid in aqueous humor and serum of patients with and without cataract; physiologic significance of relative concentrations.
复制标题
患有和不患有白内障的患者的房水和血清中的抗坏血酸；
DOI：
10.1001/archopht.1954.00920040003001
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发表时间：
1954
期刊：
影响因子：
--
通讯作者：
V. Kinsey
中科院分区：
文献类型：
--
作者：
E. Purcell;L. H. Lerner;V. Kinsey
人们试图解释房水中抗坏血酸的浓度是如何维持在血液中的浓度以上的。1提出了三种不同的机制：(1)抗坏血酸是由晶状体合成的；(2)抗坏血酸以氧化态(即脱氢抗坏血酸)被输送到睫状上皮边界，在那里它被晶状体†还原为抗坏血酸；(3)抗坏血酸被睫状体上皮选择性地浓缩，从那里扩散到后房。7‡支持将晶状体与房水中的抗坏血酸保持较高浓度联系起来的理论的主要证据是观察到当晶状体有白内障或无晶状体时，晶状体中的抗坏血酸浓度低于正常水平。例如，已经观察到房水中抗坏血酸浓度降低。
MANY ATTEMPTS have been made to explain how the concentration of ascorbic acid in the aqueous humor is maintained in excess of that in the blood.1Three different mechanisms have been proposed: (1) Ascorbic acid is synthesized by the lens *; (2) ascorbic acid is transported across the ciliary epithelial border in the oxidized state (i. e., as dehydroascorbic acid), where it is reduced to ascorbic acid by the lens †; (3) ascorbic acid is selectively concentrated by the ciliary epithelium, whence it diffuses to the posterior chamber.7‡ The chief evidence in support of the theories that associate the lens with the maintenance of relatively high concentrations of ascorbic acid in the aqueous humor is the observation that the concentration of the acid is less than normal when the lens is cataractous or absent. For instance, reduced concentrations of ascorbic acid in the aqueous humor have been observed