Cholinergic neuron-like D-U87 cells promote polarization of allergic rhinitis T-helper 2 cells

Cholinergic neuron-like D-U87 cells promote polarization of allergic rhinitis T-helper 2 cells
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胆碱能神经元样 D-U87 细胞促进过敏性鼻炎 T-辅助 2 细胞的极化

DOI:
10.1002/alr.22467
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发表时间:
2019-10-28
影响因子:
6.4
通讯作者:
Tan, Guolin
Tan, Guolin
中科院分区:
医学1区
文献类型:
--
作者:
Liu, Honghui;Wang, Tiansheng;Tan, Guolin

文献摘要

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副交感神经超敏反应与变应性鼻炎(AR)的严重程度有关,但AR患者神经免疫调节的确切机制尚不清楚。本研究探讨了胆碱能神经抑制对AR CD4+辅助性T细胞(Th)2细胞极化的影响及其体外调控机制。
Parasympathetic nerve hypersensitivity contributes to the severity of allergic rhinitis (AR), but the precise mechanism underlying neuroimmune regulation in patients with AR remains unclear. This study investigated the effect of cholinergic nerve inhibition on AR CD4+ T‐helper (Th)2‐cell polarization and the underlying regulatory mechanism in vitro.