Myelin Basic Protein synthesis is regulated by small non-coding RNA 715
Myelin Basic Protein synthesis is regulated by small non-coding RNA 715
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DOI：
10.1038/embor.2012.97
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发表时间：
2012-09-01
期刊：
影响因子：
7.7
通讯作者：
White, Robin
中科院分区：
文献类型：
--
作者：
Bauer, Nina M.;Moos, Christina;White, Robin
少突胶质髓鞘碱性蛋白（MBP）的合成是中枢神经系统髓鞘形成所必需的。在少突胶质细胞分化过程中，MBP mRNA在细胞内运输时保持翻译沉默状态，直到神经元来源的信号启动局部MBP翻译。在这里，我们确定了小的非编码RNA715 （sncRNA715）作为MBP翻译的抑制剂。SncRNA715定位于细胞质颗粒结构，并与MBP mRNA转运颗粒组分相关。我们还在脱髓鞘的慢性人类多发性硬化症病变中检测到sncRNA715水平升高，这些病变含有MBP mRNA，但缺乏MBP蛋白。
Oligodendroglial Myelin Basic Protein (MBP) synthesis is essential for myelin formation in the central nervous system. During oligodendrocyte differentiation, MBP mRNA is kept in a translationally silenced state while intracellularly transported, until neuron-derived signals initiate localized MBP translation. Here we identify the small non-coding RNA 715 (sncRNA715) as an inhibitor of MBP translation. SncRNA715 localizes to cytoplasmic granular structures and associates with MBP mRNA transport granule components. We also detect increased levels of sncRNA715 in demyelinated chronic human multiple sclerosis lesions, which contain MBP mRNA but lack MBP protein.