The cellular and molecular origins of beak morphology
The cellular and molecular origins of beak morphology
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DOI：
10.1126/science.1077827
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发表时间：
2003-01-24
期刊：
影响因子：
56.9
通讯作者：
Helms, JA
中科院分区：
文献类型：
--
作者：
Schneider, RA;Helms, JA
喙形态差异的细胞和分子机制可能涉及多个胚胎种群之间的相互作用。我们在两个解剖学上不同的物种之间交换了注定要参与喙形态发生的神经脊细胞。鸭神经脊细胞在鸭体内产生喙，鸭神经脊细胞在宿主体内产生鸭嘴。这些变化涉及到非神经脊宿主喙组织的形态变化。为了实现这些变化，供体神经脊细胞执行自主的分子程序，并调节邻近宿主组织的基因表达。因此，神经脊细胞是产生喙形态种间变异的分子信息源。
Cellular and molecular mechanisms underlying differences in beak morphology likely involve interactions among multiple embryonic populations. We exchanged neural crest cells destined to participate in beak morphogenesis between two anatomically distinct species. Quail neural crest cells produced quail beaks in duck hosts and duck neural crest produced duck bills in quail hosts. These transformations involved morphological changes to non neural crest host beak tissues. To achieve these changes, donor neural crest cells executed autonomous molecular programs and regulated gene expression in adjacent host tissues. Thus, neural crest cells are a source of molecular information that generates interspecific variation in beak morphology.