Circos: An information aesthetic for comparative genomics
Circos: An information aesthetic for comparative genomics
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DOI：
10.1101/gr.092759.109
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发表时间：
2009-09-01
期刊：
影响因子：
7
通讯作者：
Marra, Marco A.
中科院分区：
文献类型：
--
作者：
Krzywinski, Martin;Schein, Jacqueline;Marra, Marco A.
我们创建了一个名为Circos的可视化工具，以方便识别和分析基因组比较产生的相似性和差异性。我们的工具在显示基因组结构的变异以及基因组间隔之间的任何其他类型的位置关系方面是有效的。这些数据通常由序列比对、杂交阵列、基因组作图和基因分型研究产生。Circos使用圆形表意文字布局，通过使用条带来方便地显示成对位置之间的关系，条带编码相关基因组元素的位置、大小和方向。Circos能够将数据显示为散点图、直线图和直方图、热图、图块、连接器和文本。位图或矢量图像可以从gff风格的数据输入和分层配置文件中创建，可以通过自动化工具轻松生成，使Circos适合快速部署在数据分析和报告管道中。
We created a visualization tool called Circos to facilitate the identification and analysis of similarities and differences arising from comparisons of genomes. Our tool is effective in displaying variation in genome structure and, generally, any other kind of positional relationships between genomic intervals. Such data are routinely produced by sequence alignments, hybridization arrays, genome mapping, and genotyping studies. Circos uses a circular ideogram layout to facilitate the display of relationships between pairs of positions by the use of ribbons, which encode the position, size, and orientation of related genomic elements. Circos is capable of displaying data as scatter, line, and histogram plots, heat maps, tiles, connectors, and text. Bitmap or vector images can be created from GFF-style data inputs and hierarchical configuration files, which can be easily generated by automated tools, making Circos suitable for rapid deployment in data analysis and reporting pipelines.