Erythrocyte creatine as a marker of excessive erythrocyte destruction due to hypersplenism in patients with liver cirrhosis
Erythrocyte creatine as a marker of excessive erythrocyte destruction due to hypersplenism in patients with liver cirrhosis
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DOI：
10.1016/s0009-9120(01)00242-9
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发表时间：
2001-07-01
影响因子：
2.8
通讯作者：
Sugiura, T
中科院分区：
文献类型：
--
作者：
Jiao, YF;Okumiya, T;Sugiura, T
目的：红细胞肌酸是红细胞年龄的敏感标志物，可用于检测轻微和持续的溶血。脾功能增强引起的血细胞过度破坏是脾功能亢进的重要证据。本研究评估了红细胞肌酸作为肝硬化患者脾功能亢进导致红细胞过度破坏的敏感标志物的有用性。 设计和方法：通过酶法测定 50 名坏死后肝硬化患者和 50 名健康对照者的红细胞肌酸。通过超声检查测量脾脏大小，并以脾脏指数表示。结果：脾肿大患者的红细胞肌酸显着高于无脾肿大患者（p < 0.005）和健康对照者（p < 0.001），但健康对照者与无脾肿大患者之间红细胞肌酸无显着差异。 15 名红细胞肌酸异常高（> 1.8 μmol/g 血红蛋白）患者中，14 名（93%）患有脾肿大。健康对照者与有或没有脾肿大的患者之间的网织红细胞计数没有显着差异。红细胞肌酸与脾脏指数（r = 0.67；p < 0.001）和网织红细胞（r = 0.63；p < 0.001）具有良好的相关性。结论：红细胞肌酸可用于预测肝硬化患者的红细胞生成状态和评估脾功能亢进。 (C) 2001 年加拿大临床化学家协会。版权所有。
Objective: Erythrocyte creatine is a sensitive marker of erythrocyte age, and can be used to detect slight and continuous hemolysis. Excessive blood cell destruction caused by increased spleen function is important evidence of hypersplenism. This study evaluates the usefulness of erythrocyte creatine as a sensitive marker of excessive erythrocyte destruction due to hypersplenism in patients with liver cirrhosis.Design and Method: Erythrocyte creatine was determined by an enzymatic method in 50 patients with postnecrotic liver cirrhosis and 50 healthy controls. The spleen size was measured by ultrasonography and expressed as a spleen index.Results: The patients with splenomegaly showed significantly higher erythrocyte creatine than those without splenomegaly (p < 0.005) and healthy controls (p < 0.001), but there was no significant difference in erythrocyte creatine between healthy controls and those without splenomegaly. Fourteen (93%) of the 15 patients with abnormally high erythrocyte creatine (> 1.8 mu mol/g hemoglobin) had splenomegaly. There were no significant differences in reticulocyte count between healthy controls and the patients with and without splenomegaly. Erythrocyte creatine showed good correlations with spleen index (r = 0.67; p < 0.001) and reticulocytes (r = 0.63; p < 0.001).Conclusions: Erythrocyte creatine can be used for predicting erythropoietic status and estimating hypersplenism in patients with liver cirrhosis. (C) 2001 The Canadian Society of Clinical Chemists. All rights reserved.