Questions and controversies: the role of necroptosis in liver disease.
Questions and controversies: the role of necroptosis in liver disease.
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DOI：
10.1038/cddiscovery.2016.89
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发表时间：
2016
影响因子：
7
通讯作者：
中科院分区：
文献类型：
--
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急性和慢性肝损伤导致肝细胞死亡和更新。如果损伤变成慢性，持续的细胞死亡和转换导致慢性炎症、纤维化，最终导致肝硬化和肝细胞癌。控制肝细胞死亡，无论是在急性损伤中，还是在慢性损伤中，控制继发性炎症和纤维化，都是一种至关重要的治疗策略。肝细胞凋亡和坏死都发生在肝脏中，但肝脏坏死性下垂的发生及其对肝病的影响存在争议。坏死坏死是一种受调控的坏死形式，发生在某些细胞类型中，当通过激活MLKL的RIPK1-RIPK3抑制caspases（+/−cIAPs）时。最近在多种肝损伤模型中研究了肝脏坏死性上睑下垂的发生，结果相互矛盾。本综述的目的是总结已发表的数据，重点是该领域的争议和遗留问题。
Acute and chronic liver injury results in hepatocyte death and turnover. If injury becomes chronic, the continuous cell death and turnover leads to chronic inflammation, fibrosis and ultimately cirrhosis and hepatocellular carcinoma. Controlling liver cell death both in acute injury, to rescue the liver from acute liver failure, and in chronic injury, to curb secondary inflammation and fibrosis, is of paramount importance as a therapeutic strategy. Both apoptosis and necrosis occur in the liver, but the occurrence of necroptosis in the liver and its contribution to liver disease is controversial. Necroptosis is a form of regulated necrosis which occurs in certain cell types when caspases (+/−cIAPs) are inhibited through the RIPK1-RIPK3 activation of MLKL. The occurrence of necroptosis in the liver has recently been examined in multiple liver injury models with conflicting results. The aim of this review is to summarize the published data with an emphasis on the controversies and remaining questions in the field.