Role of environmental factors in the timing of puberty
Role of environmental factors in the timing of puberty
复制标题
DOI：
10.1542/peds.2007-1813c
复制
发表时间：
2008-02-01
期刊：
影响因子：
8
通讯作者：
Skakkebaek, Niels E.
中科院分区：
文献类型：
--
作者：
Euling, Susan Y.;Selevan, Sherry G.;Skakkebaek, Niels E.
从历史上看，青春期时间指标一直被用作营养充足和生长发育的指标。最近，对这些措施与雌激素或抗雄激素药物的接触以及其他环境因素的关系进行了研究。科学界一直在争论，当今美国的青春期时间是否比20世纪中期更早，如果是这样，环境因素是否起了作用；然而，没有人要求一个多学科小组来解决这个问题。因此，在“环境因素对青春期时间和进展的作用”研讨会上，由美国环境保护署、国家环境健康科学研究所和国际Serono专题讨论会联合主办的多学科专家小组召开会议，审查长期趋势的证据，确定潜在的环境因素，并确定有关环境因素和青春期时间的研究需求。大多数小组成员的结论是，女孩的数据足以表明从1940年到1994年乳房发育开始和月经初潮较早的长期趋势，但男孩的数据不足以表明同一时期的趋势。对人类和动物研究的证据权重评估表明，干扰内分泌的化学物质，特别是雌激素模拟物和抗雄激素，以及体脂是与青春期时间改变有关的重要因素。从公共卫生的角度来看，青春期标志时间的改变被认为是不利的。该小组建议研究领域，以进一步了解环境因素、青春期时间结果和其他生殖和成人疾病在个人和人群水平上的关系。
Puberty-timing measures have historically been used as indicators of adequate nutrition and growth. More recently, these measures have been examined in relation to exposure to estrogenic or antiandrogenic agents, as well as other environmental factors. The scientific community has debated whether puberty timing is occurring earlier today than in the mid-1900s in the United States and, if so, whether environmental factors play a role; however, no one has asked a multidisciplinary panel to resolve this question. Thus, a multidisciplinary expert panel jointly sponsored by the US Environmental Protection Agency, the National Institute of Environmental Health Sciences, and Serono Symposia International was convened to examine the evidence of a secular trend, identify potential environmental factors of concern, and identify research needs regarding environmental factors and puberty timing at "The Role of Environmental Factors on the Timing and Progression of Puberty" workshop. The majority of the panelists concluded that the girls' data are sufficient to suggest a secular trend toward earlier breast development onset and menarche from 1940 to 1994 but that the boys' data are insufficient to suggest a trend during this same period. The weight-of-the-evidence evaluation of human and animal studies suggest that endocrine-disrupting chemicals, particularly the estrogen mimics and antiandrogens, and body fat are important factors associated in altered puberty timing. A change in the timing of puberty markers was considered adverse from a public health perspective. The panel recommended research areas to further our understanding of the relationships among environmental factors, puberty-timing outcomes, and other reproductive and adult disease at the individual and population levels.