MINOR PHYSICAL ANOMALIES IN SCHIZOPHRENIA
MINOR PHYSICAL ANOMALIES IN SCHIZOPHRENIA
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DOI：
10.1093/schbul/15.1.91
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发表时间：
1989-01-01
影响因子：
6.6
通讯作者：
KHARABI, F
中科院分区：
文献类型：
--
作者：
GREEN, MF;SATZ, P;KHARABI, F
本研究旨在探讨躯体异常对精神分裂症早期产前损伤的评估价值。PA是头、手和脚发育的轻微异常，推测与妊娠早期的损伤有关。对67例住院精神分裂症患者和88例正常对照者进行了PA检测。精神分裂症患者比对照组表现出更多的异常。即使将患者与低社会经济地位的对照组进行比较，差异仍然显著。男性和女性患者均表现出口部异常的高发生率，女性患者表现出头围异常的高发生率。发病年龄早（≤ 18岁）的患者比发病年龄晚的患者有更多的身体异常。这种关系在男性中最为明显。身体异常与警觉性、选择性注意力或定向力的测量缺陷无关。
This study was conducted to investigate the value of using physical anomalies (PAs) to evaluate early prenatal injury in schizophrenia. PAs are minor abnormalities in development of the head, hands, and feet that are presumably associated with insult during the first trimester. Sixty-seven schizophrenic inpatients and 88 normal controls were evaluated for PAs. The schizophrenic patients showed significantly more anomalies than the controls. The difference remained significant even when patients were compared to controls of low socioeconomic status. Both male and female patients showed a high incidence of mouth abnormalities, and female patients showed a high incidence of abnormalities in head circumference. Patients with early age of onset (≤ 18 years) had more physical anomalies than did later onset patients. This relationship was most noticeable for males. Physical anomalies were not associated with deficits on measures of vigilance, selective attention, or orientation.