Inotropic response of the salvaged myocardium after acute coronary occlusion.
Inotropic response of the salvaged myocardium after acute coronary occlusion.
复制标题
急性冠状动脉闭塞后挽救的心肌的正性肌力反应。
DOI：
10.1016/s0003-4975(10)64497-9
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发表时间：
1986
期刊：
影响因子：
--
通讯作者：
Cohn,LH
中科院分区：
文献类型：
--
作者：
Berrizbeitia,LD;Piccione,W;Austin,JC;Sawtelle,K;Dance,GR;Shemin,RJ;Cohn,LH
我们测定了再灌注心肌对盐酸多巴酚丁胺正性肌力刺激的反应。15只灰狗结扎冠状动脉左前降支中段3 h。第1组（N = 8）在跳动的工作心脏中再灌注3小时。第2组（N= 7）在体外循环（CPB）1h，主动脉根部和缺血区经内乳-LAD移植物灌注钾停搏液500 ml，停转3 h。再灌注3 h后给予多巴酚丁胺10 μg/kg/min，持续20 min。局部心肌功能的测定与subendoscopic超声晶体在该地区的缺血和心脏的基础;节段收缩力的左心室压力峰值收缩末期段长度的比率确定;和全球收缩力的心室压力波的斜率确定在一个发达的压力为40毫米汞柱。在LAD闭塞前（对照）、再灌注3小时结束时（闭塞开始后6小时）和多巴酚丁胺输注20分钟后进行测量。与再灌注3小时相比，多巴酚丁胺灌注改善了所有动物的节段性功能，研究表明，在闭塞3小时和再灌注3小时后，再灌注心肌对正性肌力刺激的反应良好，并且再灌注方法对再灌注和正性肌力刺激的收缩反应都有很大影响。
We determined the response of the reperfused myocardium to inotropic stimulation with dobutamine hydrochloride. The middle part of the left anterior descending coronary artery (LAD) was occluded in 15 greyhounds for 3 hours. Group 1 (N = 8) was reperfused for 3 hours in the beating, working heart. Group 2 (N= 7) was put on cardiopulmonary bypass (CPB) for 1 hour, received 500 ml of potassium cardioplegia in the aortic root and in the area of ischemia through an internal mammary–LAD graft, and the LAD was reperfused off CPB for 3 hours. After 3 hours of reperfusion, dobutamine was given at 10 μg/kg/min for 20 minutes. Regional myocardial function was determined with subendocardial ultrasonic crystals in the area of ischemia and in the base of the heart; segmental contractility was determined from the ratio of peak left ventricular pressure to end-systolic segment length; and global contractility was determined by the slope of the ventricular pressure wave at a developed pressure of 40 mm Hg. Measurements were made prior to LAD occlusion (control), at the end of 3 hours of reperfusion (6 hours from the beginning of occlusion), and after 20 minutes of dobutamine infusion. Dobutamine infusion improved segmental function in all animals compared with 3 hours of reperfusion.The study shows that the reperfused myocardium responds favorably to inotropic stimulation after 3 hours of occlusion and 3 hours of reperfusion, and that the contractile response both to reperfusion and to inotropic stimulation is greatly affected by the method of reperfusion.