Chorionic villus sampling: experience of the first 1000 cases.
Chorionic villus sampling: experience of the first 1000 cases.
复制标题
绒毛膜绒毛取样：前1000例的经验。
DOI：
10.1016/0002-9378(86)90707-6
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发表时间：
1986
影响因子：
9.8
通讯作者：
M. Golbus
中科院分区：
文献类型：
--
作者：
W. Hogge;S. Schonberg;M. Golbus
绒毛膜绒毛取样已被广泛接受作为一种替代胎盘穿刺术产前检测遗传性疾病。我们对1000例连续病例的经验表明，自然流产后的程序是相关的孕龄进行，和率是可以接受的低（3.8%）时，程序从第九至第十一月经周进行。晚期并发症包括绒毛膜炎（0.6%）和延迟性胎膜破裂和/或羊水过少（0.8%）。在1.7%的病例中发现了绒毛核型与胎儿核型之间的差异，最常见的是绒毛样本中的嵌合体，因为在胎儿样本中未发现染色体异常。我们的结论是，虽然绒毛膜绒毛取样似乎是一个可以接受的安全和可靠的程序，需要进一步的调查前，这种早期妊娠技术被广泛使用作为替代穿刺术。
Chorionic villus sampling has become widely accepted as a first-trimester alternative to amniocentesis for the prenatal detection of genetic disorders. Our experience with 1000 consecutive cases suggests that spontaneous abortion following the procedure is related to the gestational age at which it is performed, and the rate is acceptably low (3.8%) when the procedure is performed from the ninth through the eleventh menstrual week. Later complications include chorioamnionitis (0.6%) and delayed rupture of membranes and/or oligohydramnios (0.8%). A discrepancy between the villus karyotype and that of the fetus was found in 1.7% of cases and most commonly consisted of mosaicism in the villus sample for a chromosomal abnormality that was not found in fetal samples. We conclude that although chorionic villus sampling appears to be an acceptably safe and reliable procedure, further investigation is needed before this first-trimester technique is widely utilized as an alternative to amniocentesis.