Genetics of exfoliation syndrome and glaucoma.
Genetics of exfoliation syndrome and glaucoma.
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DOI：
10.1097/iio.0000000000000042
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发表时间：
2014
影响因子：
--
通讯作者：
Allingham RR
中科院分区：
文献类型：
--
作者：
Aboobakar IF;Allingham RR
剥脱性青光眼（XFG）是世界上最常见的可识别的开角型青光眼的二级形式。它是剥脱综合征（XFS）的眼部表现，XFS是一种年龄相关的全身性疾病，其特征在于细胞外纤维状物质在各种组织和器官中的沉积。XFS/XFG已经在世界各地的人群中进行了研究，这导致了在疾病发病机制中起重要作用的遗传因素的鉴定。在这里，我们总结了XFS/XFG遗传学的现有知识，并确定了未来的研究领域。
Exfoliation glaucoma (XFG) is the most common identifiable secondary form of open-angle glaucoma in the world. It is an ocular manifestation of exfoliation syndrome (XFS), an age-related systemic disease characterized by deposition of extracellular fibrillar material in various tissues and organs. XFS/XFG has been studied in populations around the world, which has led to identification of genetic factors that play a significant role in disease pathogenesis. Here, we summarize current knowledge of the genetics of XFS/XFG and identify areas for future research.