Increased prevalence of thyroid antibodies in euthyroid women with a history of recurrent in-vitro fertilization failure
Increased prevalence of thyroid antibodies in euthyroid women with a history of recurrent in-vitro fertilization failure
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DOI：
10.1093/humrep/15.3.545
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发表时间：
2000-03-01
影响因子：
6.1
通讯作者：
Dietl, J
中科院分区：
文献类型：
--
作者：
Bussen, S;Steck, T;Dietl, J
本研究旨在评估甲状腺功能正常的妇女在体外受精（IVF）胚胎移植计划中是否存在甲状腺抗体与不良结果相关。24名女性（研究组：平均年龄+/- SD: 31.5 +/-）采用市售试剂盒检测血清中甲状腺球蛋白（TG）、甲状腺过氧化物酶抗体（TPO）和抗心磷脂抗体（IgG和IgM）的浓度。对照组为连续24例无内分泌功能障碍患者，平均年龄+/- SD: 30.3 +/- 4.1岁，在我院辅助生殖科寻求不孕不育治疗。研究组和对照组均通过促甲状腺激素（TSH）浓度正常判定甲状腺功能正常，研究组和对照组分别有13例和2例患者TG、TPO或两种甲状腺抗体均呈阳性（Fisher精确检验：P = 0.002）。与对照组相比，研究组的平均血清TG浓度显著升高（156 +/- 167 IU/ml vs 33.5 +/- 32.0 IU/ml； u检验：P = 0.009）。两组血清TPO添加抗心磷脂抗体浓度相近；我们的研究表明，甲状腺抗体可能是体外受精胚胎移植计划中生殖失败的独立标志物。
This study was undertaken to evaluate whether the presence of thyroid antibodies in euthyroid women is associated with an adverse outcome in an in-vitro fertilization (IVF)embryo transfer programme. In 24 women (study group: mean age +/- SD: 31.5 +/-. 4.4 years) who failed to conceive after having three or more cycles of IVF and embryo transfer, serum concentrations of thyroglobulin (TG), thyroid peroxidase antibodies (TPO) and anticardiolipin antibodies (IgG and IgM) were measured using commercially available kits. The control group comprised 24 consecutive patients without endocrine dysfunction (mean age +/- SD: 30.3 +/- 4.1 years) seeking infertility treatment in our department of assisted reproduction. All patients in both the study and the control groups were determined to be euthyroid by demonstrating normal concentrations of thyroid-stimulating hormone (TSH), In the study and control groups respectively, 13 and two patients demonstrated positive titres of TG, TPO or both thyroid antibodies (Fisher's exact test: P = 0.002). Mean serum concentrations of TG were significantly increased in the study group compared to the control subjects (156 +/- 167 IU/ml versus 33.5 +/- 32.0 IU/ml; U-test: P = 0.009). Serum concentrations of TPO add anticardiolipin antibodies were similar in both groups;Our investigations revealed that thyroid antibodies might be independent markers for reproductive failure in an IVF-embryo transfer programme.