Reference range of serum haptoglobin is haptoglobin phenotype-dependent in blacks
Reference range of serum haptoglobin is haptoglobin phenotype-dependent in blacks
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DOI：
10.1016/s0009-8981(00)00225-4
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发表时间：
2000-06-01
影响因子：
5
通讯作者：
Delanghe, JR
中科院分区：
文献类型：
--
作者：
Kasvosve, I;Gomo, ZAR;Delanghe, JR
血清触珠蛋白 (Hp) 的参考值是在津巴布韦黑人群体中建立的。上限（2.15 克/升）与白种人的上限相当，但下限（0.12 克/升）远低于拟议的临时国际参考限值（03 克/升）。通过淀粉凝胶电泳技术分型为Hp 0-0的受试者使用高效凝胶渗透色谱法重新分型。这导致 Hp 0-0 的频率下降 32%，但 Hp 2-2 和 Hp 2-1M 表型频率增加。在津巴布韦黑人中，Hp 0-0 频率估计为 2.9%。发现触珠蛋白参考值与 Hp 表型相关；在 Hp 1-1（中位数 0.88 g/l；范围 0.31-1.69 g/l）和 Hp 2-1（中位数 0.90 g/l；范围 0.31-2.22 g/l）中发现最高值，在 Hp 2-2 受试者中发现较低值（中位数 0.66 g/l；范围 0.13-1.79 g/l）。 Hp 2-1M 表型的特点是参考值低 (0.18-1.25 g/l) (P < 0.05)。在罕见变体 Hp Johnson 的三个病例中，发现了高 Hp 浓度（中位数 1.57 g/l；范围 0.98-1.57 g/l）。 (C) 2000 Elsevier Science B.V. 保留所有权利。
Reference values for serum haptoglobin (Hp), were established in a Black Zimbabwean population. The upper limit (2.15 g/l) is comparable to the one in Caucasians, but the lower limit (0.12 g/l) is much lower than the proposed interim international reference limit (03 g/l). Subjects that typed as Hp 0-0 by starch gel electrophoresis technique were retyped using high performance gel permeation chromatography. This resulted in a 32% decrease in the Frequency of Hp 0-0, but an increase in Hp 2-2 and Hp 2-1M phenotype frequencies. In the Zimbabwean Blacks, the Hp 0-0 Frequency was estimated to be 2.9%. Haptoglobin reference values were found to be Hp phenotype-dependent; highest values were found in Hp 1-1 (median 0.88 g/l; range 0.31-1.69 g/l) and in Hp 2-1 (median 0.90 g/l; range 0.31-2.22 g/l) and lower values (median 0.66 g/l; range 0.13-1.79 g/l) in Hp 2-2 subjects. The Hp 2-1M phenotype was characterized by low reference values (0.18-1.25 g/l) (P < 0.05), In three cases of the rare variant Hp Johnson, high Hp concentrations were found (median 1.57 g/l; range 0.98-1.57 g/l). (C) 2000 Elsevier Science B.V. All rights reserved.