Preliminary experience in treating lymphocytic leukaemia with antibody to immunoglobulin idiotypes on the cell surfaces.
Preliminary experience in treating lymphocytic leukaemia with antibody to immunoglobulin idiotypes on the cell surfaces.
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DOI：
10.1038/bjc.1980.271
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发表时间：
1980-10
影响因子：
8.8
通讯作者：
Stevenson, G T
中科院分区：
文献类型：
--
作者：
Hamblin, T J;Abdul-Ahad, A K;Gordon, J;Stevenson, F K;Stevenson, G T
针对1例慢性淋巴细胞性白血病(原淋巴细胞性变异型)患者肿瘤淋巴细胞表面免疫球蛋白的独特型决定簇，用绵羊制备了肿瘤特异性抗血清。从单分散的血清中制备补体激活的抗独特型IgG1亚类供输注。两个剂量分别为480毫克和1200毫克的试验组的白细胞数分别下降了三分之一和一半。然而，病情迅速回升，因此在每次治疗8天后，计数恢复到以前水平的大约85%。脾大小和淋巴结大小无明显变化。每种治疗方法可能破坏4-8X10(11)个细胞，约占总肿瘤负荷的10%。抗体被迅速消耗，有证据表明补体的大量使用。
Tumour-specific antiserum was raised in sheep against idiotypic determinants on the surface immunoglobulin of neoplastic lymphocytes from a patient with chronic lymphocytic leukaemia (prolymphocytic variant). The complement-activating IgG1 subclass of the anti-idiotype was prepared from the serum in monodisperse form for infusion. Two treatments of 480 and 1200 mg caused the white-cell count to fall by one-third and one-half respectively. However, there was a rapid resurgence, so that by 8 days after each treatment the counts were restored to approximately 85% of their former levels. No change was noted in the size of spleen or lymph nodes. Each treatment probably destroyed 4-8 X 10(11) cells, some 10% of the total tumour load. The antibody was rapidly consumed, and there was evidence of heavy utilization of complement.