Embryology of the Biliary Tract
Embryology of the Biliary Tract
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DOI：
10.1159/000286463
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发表时间：
2010-01-01
影响因子：
2.7
通讯作者：
Ando, Hisami
中科院分区：
文献类型：
--
作者：
Ando, Hisami
在人类胚胎发育的宫内生活的第4周早期，原始中肠的腹壁出现肝憩室。这个小憩室是肝脏、肝外胆管、胆囊腺和腹侧胰腺发育的原基。到第5周，胆道树的所有成分都可以辨认出来。随着上皮细胞堵塞管腔，胆总管明显延长。胆总管管腔再通始于第5周末，向远端缓慢移动。到第6周时，总胆管和腹侧胰芽绕十二指肠顺时针旋转180圈。在第7周早期，胆管和胰管终止于十二指肠的闭合腔内。8~12周龄时，肝胰管既有上口也有下口。在这两个孔中，较低的那个通常被抑制。Oddi括约肌由围绕胆管和胰管前叶部分的同心间充质环发育而来。在第10周左右，Oddi括约肌开始分化。在第16周，固有肌从窗外延伸到壶腹上端。到第28周，固有肌几乎分化到壶腹的远端。版权所有(C)2010 S.Karger AG，巴塞尔
A hepatic diverticulum appears in the ventral wall of the primitive midgut early in the 4th week of intrauterine life in the development of the human embryo. This small diverticulum is the anlage for the development of the liver, extrahepatic biliary ducts, gallbladder, and ventral pancreas. By the 5th week, all elements of the biliary tree are recognizable. Marked elongation of the common duct occurs with plugging of the lumen by epithelial cells. Recanalization of the lumen of the common duct starts at the end of the 5th week and moves slowly distally. By the 6th week, the common duct and ventral pancreatic bud rotate 180 clockwise around the duodenum. Early in the 7th week, the bile and pancreatic ducts end in closed cavities of the duodenum. Between the early 8th and 12th week, hepatopancreatic ducts have both superior and inferior orifices. Of these two orifices, the inferior one is usually suppressed. The muscle of the sphincter of Oddi develops from a concentric ring of mesenchyme surrounding the preampullary portion of the bile and pancreatic ducts. At about the 10th week, the muscle of the sphincter of Oddi undergoes differentiation. In the 16th week, the muscularis propria extends from just outside the fenestra to the upper end of the ampulla. By the 28th week, the musculus proprius is differentiated almost to the distal end of the ampulla. Copyright (C) 2010 S. Karger AG, Basel