Foxp1 is an essential transcriptional regulator of B cell development
Foxp1 is an essential transcriptional regulator of B cell development
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DOI：
10.1038/ni1358
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发表时间：
2006-08-01
影响因子：
30.5
通讯作者：
Rao, Anjana
中科院分区：
文献类型：
--
作者：
Hu, Hui;Wang, Bin;Rao, Anjana
叉头转录因子是发育和免疫调节的关键参与者。在这里，我们证明了叉头转录因子Foxp1编码基因的缺失导致了早期B细胞发育的严重缺陷。Foxp 1缺陷与B220（+）胎肝细胞中所有B谱系基因的表达降低以及从前B细胞向前B细胞转化的阻滞相关，包括重组激活基因1和2的表达降低。Foxp 1与Erag增强子结合，并以B细胞谱系特异性方式参与控制编码免疫球蛋白重链的基因的可变（多样性）连接重组。我们的研究结果确定Foxp1作为B淋巴细胞生成的转录调控网络的重要参与者。
Forkhead transcription factors are key participants in development and immune regulation. Here we demonstrate that absence of the gene encoding the forkhead transcription factor Foxp1 resulted in a profound defect in early B cell development. Foxp1 deficiency was associated with decreased expression of all B lineage genes in B220(+) fetal liver cells as well as with a block in the transition from pro-B cell to pre-B cell involving diminished expression of recombination-activating genes 1 and 2. Foxp1 bound to the Erag enhancer and was involved in controlling variable-(diversity)-joining recombination of the gene encoding immunoglobulin heavy chain in a B cell lineage - specific way. Our results identify Foxp1 as an essential participant in the transcriptional regulatory network of B lymphopoiesis.