Design of biointerfaces composed of soft materials using controlled radical polymerizations
Design of biointerfaces composed of soft materials using controlled radical polymerizations
复制标题
使用受控自由基聚合设计由软材料组成的生物界面
DOI：
10.1039/d1tb02508b
复制
发表时间：
2022
影响因子：
7
通讯作者：
Takai Madoka
中科院分区：
文献类型：
--
作者：
Masuda Tsukuru;Takai Madoka
软界面材料在改善生物界面方面具有巨大的潜力，生物界面是生物和人工设计材料的界面。在纳米水平上控制界面的化学和物理结构对于理解功能及其应用的机制起着重要作用。可控自由基聚合（CRP）技术，包括原子转移自由基聚合（ATRP）和可逆加成-断裂链转移聚合（RAFT），已在精密高分子化学领域得到发展。它允许形成良好定义的表面，如密集堆积的聚合物刷和嵌段共聚物的自组装纳米结构。最近，还开发了一种制备含有生物分子的聚合物的新技术，称为生物杂化物，这是CRP进步的结果，以便在具有氧气的水性介质中进行。本文综述了CRP在生物界面设计中的最新进展。
Soft interface materials have an immense potential for the improvement of biointerfaces, which are the interface of biological and artificially designed materials. Controlling the chemical and physical structures of the interfaces at the nanometer level plays an important role in understanding the mechanism of the functioning and its applications. Controlled radical polymerization (CRP) techniques, including atom transfer radical polymerization (ATRP) and reversible addition–fragmentation chain-transfer (RAFT) polymerization, have been developed in the field of precision polymer chemistry. It allows the formation of well-defined surfaces such as densely packed polymer brushes and self-assembled nanostructures of block copolymers. More recently, a novel technique to prepare polymers containing biomolecules, called biohybrids, has also been developed, which is a consequence of the advancement of CRP so as to proceed in an aqueous media with oxygen. This review article summarizes recent advances in CRP for the design of biointerfaces.