Callicarpa longissima extract, carnosol-rich, potently inhibits melanogenesis in B16F10 melanoma cells
Callicarpa longissima extract, carnosol-rich, potently inhibits melanogenesis in B16F10 melanoma cells
复制标题
长紫珠提取物富含鼠尾草酚，可有效抑制 B16F10 黑色素瘤细胞中的黑色素生成
DOI：
10.1007/s11418-015-0933-5
复制
发表时间：
2016
期刊：
影响因子：
--
通讯作者：
H. Watanabe
中科院分区：
文献类型：
--
作者：
M. Yamahara;K. Sugimura;A. Kumagai;H. Fuchino;A. Kuroi;M. Kagawa;Y. Itoh;H. Kawahara;Y. Nagaoka;O. Iida;N. Kawahara;H. Takemori;H. Watanabe
化妆品行业专注于开发调节皮肤色素沉着的材料和资源。黑色素是人体皮肤中的主要色素，可以保护皮肤免受紫外线的伤害。长紫珠叶的乙醇提取物通过抑制小眼球相关转录因子 (MITF) 基因的表达来抑制 B16F10 小鼠黑色素瘤细胞中黑色素的产生。使用液相色谱-质谱 (LC-MS)、NMR 和生化测定进行纯化和分析后，确定鼠尾草酚是 theC 的主要抑制作用的原因。 longissima 提取物对黑色素产生的影响。鼠尾草酚是鼠尾草酸的氧化产物，其在提取物中的存在也得到了可靠的参考文献的证实。提取物中鼠尾草酚和鼠尾草酸含量约为 16%（w/w）。这些结果表明C. longissimai 是一种新颖、有用且有吸引力的皮肤美白剂来源。
Cosmetic industries focus on developing materials and resources that regulate skin pigmentation. Melanin, the major pigment in human skin, protects the skin against damage from ultraviolet light. An ethanolic extract of the leaves ofCallicarpa longissimainhibits melanin production in B16F10 mouse melanoma cells by suppressing microphthalmia-associated transcription factor (MITF) gene expression. Following purification and analysis using liquid chromatography–mass spectrometry (LC–MS), NMR, and biochemical assays, carnosol was determined to be responsible for the major inhibitory effect of theC. longissimaextract on melanin production. Carnosol is an oxidative product of carnosic acid, whose presence in the extract was also confirmed by an authentic reference. The carnosol and carnosic acid content in the extract was approximately 16 % (w/w). These results suggest thatC. longissimais a novel, useful, and attractive source of skin-whitening agents.