Current concepts in combination antibiotic therapy for critically ill patients
Current concepts in combination antibiotic therapy for critically ill patients
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DOI：
10.4103/0972-5229.132495
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发表时间：
2014-05-01
影响因子：
2
通讯作者：
Baronia, Arvind Kumar
中科院分区：
文献类型：
--
作者：
Ahmed, Armin;Azim, Afzal;Baronia, Arvind Kumar
多重耐药（MDR）细菌病原体的广泛出现是一个全球性问题。耐多药感染很难治疗，并且常常导致高死亡率。通常使用不止一种抗生素来治疗此类感染，但科学证据并不支持在大多数情况下使用联合疗法。然而，对于某些亚组，联合治疗可能是有益的，例如碳青霉烯类耐药肠杆菌（CRE）引起的败血症、菌血症性肺炎球菌肺炎以及多器官衰竭患者。需要精心设计的前瞻性研究来明确联合治疗在这些亚组中的作用。
Widespread emergence of multidrug resistant (MDR) bacterial pathogens is a problem of global dimension. MDR infections are difficult to treat and frequently associated with high mortality. More than one antibiotic is commonly used to treat such infections, but scientific evidence does not favor use of combination therapy in most cases. However, there are certain subgroups where combination therapy may be beneficial, e.g. sepsis due to carbapenem-resistant Enterobacteriaceae (CRE), bacteremic pneumococcal pneumonia, and patients with multiple organ failure. Well-designed prospective studies are needed to clearly define the role of combination therapy in these subgroups.