Ceramide modulates the lipid membrane organization at molecular and supramolecular levels
Ceramide modulates the lipid membrane organization at molecular and supramolecular levels
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DOI：
10.1016/s0009-3084(02)00185-8
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发表时间：
2003-01-01
影响因子：
3.4
通讯作者：
Maggio, B
中科院分区：
文献类型：
--
作者：
Carrer, DC;Härtel, S;Maggio, B
脂质在膜中的作用已迅速从静态转变为动态，并强调其参与信息转导，通过成分驱动效应将时间和拓扑结构联系起来。神经酰胺已被描述为不同膜功能的重要调节剂。在与神经节苷脂GM1的混合物中，神经酰胺诱导的缩合增加了分子间的相互作用，导致相变温度和自组装结构的尺寸增加。在与磷脂酰胆碱的混合物中，神经酰胺在凝胶状态下横向分离，形成其厚度取决于鞘脂的全局浓度和链不对称性的域。(C)2002爱思唯尔科学爱尔兰有限公司保留所有权利。
The role of lipids in membranes has changed rapidly from static to dynamic and emphasized their involvement in information transduction, linking temporal and topological structuring through compositionally driven effects. Ceramide has been described as an important modulator of different membrane functions. In mixtures with ganglioside GM1, the condensation induced by ceramide increases intermolecular interactions, leading to an increase of the phase transition temperature and size of the self-assembled structure. In mixtures with phosphatidylcholines, ceramide segregates laterally in the gel state, forming domains whose thickness depend on global concentration and chain asymmetry of the sphingolipid. (C) 2002 Elsevier Science Ireland Ltd. All rights reserved.