Metabolic response to radiation therapy in cancer.
Metabolic response to radiation therapy in cancer.
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DOI：
10.1002/mc.23379
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发表时间：
2022-02
影响因子：
4.6
通讯作者：
Kesarwala, Aparna H.
中科院分区：
文献类型：
--
作者：
Read, Graham H.;Bailleul, Justine;Vlashi, Erina;Kesarwala, Aparna H.
肿瘤代谢已成为癌症的标志，并参与致癌和肿瘤生长。肿瘤代谢的重新编程对于癌细胞维持高增殖率和增强的营养需求是必要的。最近的研究表明，癌细胞中的代谢可塑性可以通过增强抗氧化防御和DNA修复机制来降低抗癌治疗的疗效。然而，很少有可靠的研究表征癌症放射治疗引起的代谢变化。对辐射诱导的代谢变化的广泛研究将导致更好地理解辐射反应机制以及识别新的治疗靶点。在这篇综述中，我们将重点介绍辐射和氧化应激在癌细胞中诱导的代谢变化及其机制的研究。
Tumor metabolism has emerged as a hallmark of cancer and is involved in carcinogenesis and tumor growth. Reprogramming of tumor metabolism is necessary for cancer cells to sustain high proliferation rates and enhanced demands for nutrients. Recent studies suggest that metabolic plasticity in cancer cells can decrease the efficacy of anticancer therapies by enhancing antioxidant defenses and DNA repair mechanisms. However, there are few robust studies characterizing the metabolic changes induced by radiation therapy in cancer. Extensive study of radiation-induced metabolic changes will lead to a better understanding of radiation response mechanisms as well as the identification of new therapeutic targets. In this review, we will highlight studies that provide information on the metabolic changes induced by radiation and oxidative stress in cancer cells and the underlying mechanisms.
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影响因子：
5.7
作者：
Bola BM;Chadwick AL;Michopoulos F;Blount KG;Telfer BA;Williams KJ;Smith PD;Critchlow SE;Stratford IJ
通讯作者：
Stratford IJ
DOI：
10.1126/science.1211485
发表时间：
2011-12-02
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Anastasiou D;Poulogiannis G;Asara JM;Boxer MB;Jiang JK;Shen M;Bellinger G;Sasaki AT;Locasale JW;Auld DS;Thomas CJ;Vander Heiden MG;Cantley LC
通讯作者：
Cantley LC
影响因子：
4
作者：
AbuSalim, Jenna E.;Yamamoto, Kazutoshi;Miura, Natsuko;Blackman, Burchelle;Brender, Jeffrey R.;Mushti, Chandrasekhar;Seki, Tomohiro;Camphausen, Kevin A.;Swenson, Rolf E.;Krishna, Murali C.;Kesarwala, Aparna H.
通讯作者：
Kesarwala, Aparna H.
影响因子：
3.7
作者：
Barjaktarovic Z;Schmaltz D;Shyla A;Azimzadeh O;Schulz S;Haagen J;Dörr W;Sarioglu H;Schäfer A;Atkinson MJ;Zischka H;Tapio S
通讯作者：
Tapio S
影响因子：
9.3
作者：
Bollineni, Vikram R.;Kerner, Gerald S. M. A.;Langendijk, Johannes A.
通讯作者：
Langendijk, Johannes A.