Increased Serum Interleukin-34 in Patients with Coronary Artery Disease
Increased Serum Interleukin-34 in Patients with Coronary Artery Disease
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DOI：
10.1177/030006051204000525
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发表时间：
2012-09-01
影响因子：
1.6
通讯作者：
Chen, Zhiqiang
中科院分区：
文献类型：
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作者：
Li, Zhenglong;Jin, Daoqun;Chen, Zhiqiang
目的：本研究旨在探讨冠心病患者血清中促炎细胞因子白细胞介素（IL）-34水平的变化。方法：91例冠心病患者（包括稳定型和不稳定型心绞痛）行冠状动脉造影后分为冠心病组（冠脉狭窄≥ 50%）和对照组（冠脉狭窄< 50%）。检测血清IL-34、超敏C反应蛋白（hs-CRP）水平。研究结果：CAD组的IL-34和hs-CRP水平显著高于对照组（分别为191.3 +/- 17.9 pg/ml vs 125.4 +/- 14.8 pg/ml和3.08 +/- 1.81 mg/ml vs 1.42 +/- 1.01 mg/ml），CAD组的IL-34和hs-CRP水平之间存在显著正相关。多元回归分析显示IL-34和hs-CRP水平是冠心病的独立预测因子（IL-34：OR 2.073，95%CI 1.419，2.672; hs-CRP：OR 1.878，95%CI 1.172，2.531）。结论：IL-34水平在冠心病患者中显著升高，且与hs-CRP水平呈正相关，提示IL-34可能是冠心病的独立预测因子。
OBJECTIVE: This study investigated levels of interleukin (IL)-34, a proinflammatory cytokine, in patients with coronary artery disease (CAD). METHODS: Following coronary artery angiography, 91 patients with CAD (including stable and unstable angina pectoris) were divided into two groups, the CAD group (coronary artery stenosis >= 50%) and the control group (coronary artery stenosis < 50%). Serum levels of factors including IL-34 and high sensitivity C-reactive protein (hs-CRP) were measured. RESULTS: IL-34 and hs-CRP levels were significantly higher in the CAD group than in the control group (191.3 +/- 17.9 pg/ml versus 125.4 +/- 14.8 pg/ml and 3.08 +/- 1.81 mg/ml versus 1.42 +/- 1.01 mg/ml, respectively), with a significantly positive correlation between IL-34 and hs-CRP levels in the CAD group. Multiple regression analysis showed that IL-34 and hs-CRP levels were independent predictors of CAD (IL-34: odds ratio [OR] 2.073, 95% confidence intervals (CI) 1.419, 2.672; hs-CRP: OR 1.878, 95% CI 1.172, 2.531). CONCLUSIONS: IL-34 levels were significantly increased in patients with CAD, and positively correlated with hs-CRP levels, suggesting that IL-34 may be an independent predictor of CAD.