A Powerful Reagent for Synthesis of Weinreb Amides Directly from Carboxylic Acids
A Powerful Reagent for Synthesis of Weinreb Amides Directly from Carboxylic Acids
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DOI：
10.1021/ol901886u
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发表时间：
2009-10-01
期刊：
影响因子：
5.2
通讯作者：
Hu, Yulai
中科院分区：
文献类型：
--
作者：
Niu, Teng;Zhang, Weiming;Hu, Yulai
开发了一种用于羧酸直接转化为Weinreb酰胺的强试剂P[NCH_3（OCH_3）]（3）（3）。在大多数情况下，当P[NCH_3（OCH_3）_（13）]与芳香族和脂肪族羧酸在甲苯中加热时，相应的Weinreb酰胺的产率在90%以上。空间位阻羧酸也可以以优异的产率得到相应的Weinreb酰胺。
A powerful reagent, P[NCH3(OCH3)](3) (3), for conversion of carboxylic acids directly to Weinreb amides was developed. In most cases the yields of the corresponding Weinreb amides were above 90% when P[NCH3(OCH3)13 was heated with aromatic and aliphatic carboxylic acids in toluene. The sterically hindered carboxylic acids can also give the corresponding Weinreb amides in excellent yields.