A CASE-CONTROL STUDY OF ALZHEIMERS-DISEASE
A CASE-CONTROL STUDY OF ALZHEIMERS-DISEASE
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DOI：
10.1002/ana.410280607
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发表时间：
1990-12-01
影响因子：
11.2
通讯作者：
RASKIND, M
中科院分区：
文献类型：
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作者：
GRAVES, AB;WHITE, E;RASKIND, M
通过对阿尔茨海默病-S病(AD)的病例对照研究，探讨痴呆家族史和AD家族史、疾病状况，特别是与AD的病毒和免疫假说有关的因素在AD发病中的作用。1980年至1985年通过华盛顿大学医院的老年和家庭服务诊所确诊了183名临床确诊患者，同期通过位于美国华盛顿州西雅图的退伍军人S行政医疗中心确诊了18名患者。电话访谈对患者的配偶(87.7%)和子女(12.3%)进行了采访。每个患者与患者的朋友或非血缘亲属通过年龄、性别以及患者与他或她的受访者之间的关系进行匹配，总共有130对匹配。如果一级亲属被报告有痴呆史，AD的优势比会增加(优势比，2.21；95%可信区间，1.17到4.18)。如果兄弟姐妹受到影响，风险尤其增加(优势比，4.04；95%可信区间，1.37至11.90)；先证者风险最高，如果兄弟姐妹被推定为AD(优势比，5.92；95%可信区间，1.59至21.96)。随着患有痴呆症和推定阿尔茨海默病的一级家庭成员数量的增加，风险也会增加。我们发现在受试者S出生时母亲或父亲的年龄在患者和对照组之间几乎没有差别。在可能支持阿尔茨海默病、吸烟或酒精问题的免疫和病毒假说方面，两组之间没有统计上的显著差异。
A case-control study of Alzheimer''s disease (AD) was conducted to evaluate the roles of family history of dementing disease and AD, and medical conditions, particularly those related to the viral and immune hypotheses in AD. One hundred and eighty-three clinically diagnosed patients were identified between 1980 and 1985 through the Geriatric and Family Services clinic at the University of Washington hospital, and 18 patients were identified during the same time period through the Veteran''s Administration Medical Center in Seattle, Washington, U.S.A. Telephone interviews were conducted with spouses (87.7%) and children (12.3%) of the patients. Each patient was matched to a friend or non-blood relative of the patient by age, sex, and the relationship between the patient and his or her respondent, for a total of 130 matched pairs. The odds ratio for AD was elevated if a first-degree relative was reported to have a history of dementia (odds ratio, 2.21; 95% confidence interval, 1.17 to 4.18). The risk was especially elevated if a sibling was affected (odds ratio, 4.04; 95% confidence interval, 1.37 to 11.90); the highest risk to the proband was observed if a sibling had presumed AD (odds ratio, 5.92; 95% confidence interval, 1.59 to 21.96). The risk increased with increasing numbers of first-degree family members affected for both a history of dementia and presumed AD. We found little difference between patients and control subjects with respect to the age of the mother or father at the time of the subject''s birth. No statistically significant differences was observed between the two groups with regard to conditions that might support the immune and viral hypothesis in AD, smoking, or alcohol problems.