RNA Degradation in Saccharomyces cerevisae
RNA Degradation in Saccharomyces cerevisae
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DOI：
10.1534/genetics.111.137265
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发表时间：
2012-07-01
期刊：
影响因子：
3.3
通讯作者：
Parker, Roy
中科院分区：
文献类型：
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作者：
Parker, Roy
酵母细胞中的所有RNA种类都经历周转。在过去的20年里，研究人员已经确定了信使RNA、转运RNA、核糖体RNA和非编码RNA的降解机制。此外，已经鉴定了许多靶向异常RNA的质量控制机制。通常，每种衰变机制都含有将RNA底物汇集到丰富的核酸外切酶和/或核酸内切酶的因子。未来工作的关键问题包括确定控制RNA降解特异性的机制以及RNA降解过程如何与翻译，RNA运输和其他细胞过程相互作用。
All RNA species in yeast cells are subject to turnover. Work over the past 20 years has defined degradation mechanisms for messenger RNAs, transfer RNAs, ribosomal RNAs, and noncoding RNAs. In addition, numerous quality control mechanisms that target aberrant RNAs have been identified. Generally, each decay mechanism contains factors that funnel RNA substrates to abundant exo- and/or endonucleases. Key issues for future work include determining the mechanisms that control the specificity of RNA degradation and how RNA degradation processes interact with translation, RNA transport, and other cellular processes.