Coinfection with malaria and intestinal parasites, and its association with anaemia in children in Cameroon
Coinfection with malaria and intestinal parasites, and its association with anaemia in children in Cameroon
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DOI：
10.1186/s40249-015-0078-5
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发表时间：
2015-10-06
影响因子：
8.1
通讯作者：
Kwenti, Tebit Emmanuel
中科院分区：
文献类型：
--
作者：
Njunda, Anna Longdoh;Fon, Shuri Ghasarah;Kwenti, Tebit Emmanuel
背景资料：本研究的目的是确定合并感染疟疾和肠道寄生虫的患病率，以及确定其与贫血的儿童年龄在10岁及以下的Muyuka，Cameroon.Materials and Methods：这是一个横断面研究。参与者是2012年4月至10月期间在Muyuka地区医院住院的发热儿童。从同意参加研究的参与者中采集血液和粪便样本。使用自动血液分析仪（Mindray（R），BC-2800）进行血红蛋白浓度（Hb）和全血细胞计数（CBC）。吉姆萨染色血膜检查疟疾寄生虫，而甲醛-乙醚浓缩技术用于检测肠道寄生虫感染（IPIs）。结果：411名儿童成功地参与了本研究。疟疾、IPIs、疟疾和IPIs合并感染和贫血的患病率分别为98.5%、11.9%、11.9%和44.8%。贫血和IPIs与年龄显著相关;贫血在5岁以下儿童中更普遍（p = 0.000），而IPIs在5至10岁儿童中更普遍（p = 0.006）。分离出的寄生虫种包括蛔虫（36 [73.5%]）、溶组织内阿米巴/dispar（9 [18.4%]）和钩虫（4 [8.2%]）。观察到的平均Hb为10.64 g/dl（+/- 1.82）。疟原虫密度与血红蛋白呈显著负相关。在感染疟疾、IPI或疟疾和IPI合并感染的儿童中，或在未感染的儿童中，贫血患病率没有显著差异。同样，平均血红蛋白感染和非感染的children.Conclusion：这项研究表明，疟疾和IPIs仍然构成一个主要的公共卫生问题，在研究领域，尽管缺乏任何显着的关联，这些感染和贫血。研究结果表明，有必要实施控制措施，以遏制研究地区的疟疾和IPIs的发病率。
Background: The purpose of this study was to determine the prevalence of coinfection with malaria and intestinal parasites, as well as to determine its association with anaemia in children aged 10 years and below in Muyuka, Cameroon.Materials and methods: This was a cross-sectional study. Participants were febrile children who were admitted to the Muyuka district hospital between April and October 2012. Blood and stool samples were collected from those participants who gave consent to take part in the study. Haemoglobin concentration (Hb) and complete blood count (CBC) were performed using an automated haematology analyser (Mindray (R), BC-2800). Giemsa-stained blood film was examined to detect malaria parasites, while the formol-ether concentration technique was used to detect intestinal parasitic infections (IPIs). The Pearson's chi-square, Student's T-test and correlation analysis were all performed as part of the statistical analyses.Results: Four hundred and eleven (411) children successfully took part in this study. The prevalence of malaria, IPIs, malaria and IPI coinfection, and anaemia observed were 98.5 %, 11.9 %, 11.9 % and 44.8 %, respectively. Anaemia and IPIs were significantly associated with age; anaemia was more prevalent in children under five years of age (p = 0.000), whereas IPIs were more prevalent in children aged between five and 10 years (p = 0.006). The parasite species isolated included Ascaris lumbricoides (36 [73.5 %]), Entamoeba histolytica/dispar (9 [18.4 %]) and hookworm (4 [8.2 %]). The mean Hb observed was 10.64 g/dl (+/- 1.82). A significant negative correlation was observed between malaria parasite density and Hb. There was no significant difference in the prevalence of anaemia among children infected with malaria, IPIs, or malaria and IPI coinfection, or among non-infected children. Similarly, the mean Hb did not differ among infected and non-infected children.Conclusion: This study showed that malaria and IPIs still constitute a major public health problem in the study area despite a lack of any significant association between these infections and anaemia. The findings suggest that there is a need for the implementation of control measures to curb the rate of malaria and IPIs in the study area.