Recurrent TERT promoter mutations in non-small cell lung cancers
Recurrent TERT promoter mutations in non-small cell lung cancers
复制标题
非小细胞肺癌中反复出现的 TERT 启动子突变。
DOI：
10.1016/j.lungcan.2014.10.009
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发表时间：
2014-12-01
期刊：
影响因子：
5.3
通讯作者：
Chen, Haiquan
中科院分区：
文献类型：
--
作者：
Ma, Xiao;Gong, Ranxia;Chen, Haiquan
Introduction: The recurrent TERT promoter mutations have been recently described in diverse human cancers. We previously showed that over 60% of non-small cell lung cancer from East Asian harbored well-known oncogenic mutations in EGFR and KRAS. Here, we sought to determine the incidence, clinicopathologic characteristics, and association with known oncogenic mutations.Patients and methods: A total of 467 patients treated surgically for primary lung cancer were examined for mutations in TERT promoter using polymerase chain reaction (PCR) followed by Sanger sequencing. Immunohistochemical (IHC) staining was performed to detect the expression of TERT. Clinical characteristics including gender, age, smoking status, tumor size, differentiation, lymph node metastasis, TNM stage, overall survival and relapse-free survival were analyzed.Results: Of 467 patients with non-small cell lung cancer, the TERT promoter mutation was detected in 12 patients. Of the 12 patients, 3 with C228T, 2 with C250T, 2 with C216T, 1 with C228A, 1 with C229G, 1 with G267C, 1 with C295T and 1 with G233C. Compared to the TERT mutation negative group, patients with TERT promoter mutation were significantly associated with older age (>= 60 years, p = 0.039). No significant difference was found in overall survival (OS) or relapse-free survival (RFS) between TERT with mutation and TERT without mutation.Conclusions: TERT promoter mutations are recurrent mutated in 2.57% of NSCLCs and are highly enriched in older patients. It may play an important role in the pathogenesis of NSCLC and may serve as a potential target for therapy. (C) 2014 Elsevier Ireland Ltd. All rights reserved.
