Retinal thickness in Parkinson's disease
Retinal thickness in Parkinson's disease
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DOI：
10.1016/j.parkreldis.2011.03.004
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发表时间：
2011-07-01
影响因子：
4.1
通讯作者：
Burn, D. J.
中科院分区：
文献类型：
--
作者：
Archibald, N. K.;Clarke, M. P.;Burn, D. J.
背景资料：视觉症状在帕金森氏病中很常见，研究一致表明视觉敏锐度、对比敏感度、颜色和运动感知的降低以及视网膜电图潜伏期和振幅的改变。光学相干断层扫描可以无创地检查视网膜结构，并且视网膜变薄已被认为是帕金森病神经变性的潜在生物标志物。我们的目的是检查帕金森病患者的视网膜厚度（和年龄匹配的对照组），以确定光学相干断层扫描在有代表性的老年帕金森病组中的实际效用。51名帕金森病患者和25名健康对照者接受了眼科评估和光学相干断层扫描（Zeiss Stratus 3000（TM））的黄斑厚度和体积以及视神经头周围的视网膜神经纤维厚度。24%的对照组和20%的帕金森病受试者因合并眼部病理而被排除在最终分析之外。由于光学相干断层扫描的耐受性差或扫描质量差，进一步的数据被排除在外。结果：尽管在剩余的可评估帕金森病队列中视力和对比敏感度降低，但与先前发表的工作相比，我们没有发现两个研究组之间在视网膜厚度的任何测量方面存在任何差异。除了评价中固有的技术问题外，帕金森病和健康对照受试者之间缺乏差异表明，需要采用更新技术进行纵向研究，以确定光学相干断层扫描作为潜在诊断生物标志物的作用。(C)2011爱思唯尔有限公司版权所有。
Background: Visual symptoms are common in Parkinson's disease with studies consistently demonstrating reductions in visual acuity, contrast sensitivity, colour and motion perception as well as alterations in electroretinogram latencies and amplitudes. Optical coherence tomography can examine retinal structure non-invasively and retinal thinning has been suggested as a potential biomarker for neurodegeneration in Parkinson's disease. Our aim was to examine the retinal thickness of a cohort of Parkinson's disease subjects (and age-matched controls) to establish the practical utility of optical coherence tomography in a representative older Parkinson's disease group.Methods: Fifty-one established Parkinson's disease subjects and 25 healthy controls were subjected to ophthalmological assessment and optical coherence tomography (Zeiss Stratus 3000 (TM)) of macular thickness and volume and retinal nerve fibre thickness around the optic nerve head. Twenty four percent of control and 20% of Parkinson's disease subjects were excluded from final analysis due to co-morbid ocular pathology. Further data was excluded either due to poor tolerability of optical coherence tomography or poor quality scans.Results: Despite a reduction in both visual acuity and contrast sensitivity in the residual evaluable Parkinson's disease cohort, we did not detect any differences between the two study groups for any measures of retinal thickness, in contrast to previously published work.Conclusions: In addition to technical problems inherent in the evaluation, the lack of difference between Parkinson's disease and healthy control subjects suggests longitudinal studies, employing newer techniques, will be required to define the role of optical coherence tomography as a potential diagnostic biomarker. (C) 2011 Elsevier Ltd. All rights reserved.