CHANGE IN PERMEABILITY OF LIPOSOMES CAUSED BY METHYLMERCURY AND INORGANIC MERCURY
CHANGE IN PERMEABILITY OF LIPOSOMES CAUSED BY METHYLMERCURY AND INORGANIC MERCURY
复制标题
DOI：
10.1016/0009-2797(78)90146-1
复制
发表时间：
1978-01-01
影响因子：
5.1
通讯作者：
IMURA, N
中科院分区：
文献类型：
--
作者：
NAKADA, S;INOUE, K;IMURA, N
The effects of 2 mercurial compounds, methyl mercury and inorganic Hg, on animal and bacterial lipids were examined by measuring permeability change of lipid bilayer, liposome. Both decrease in the cholesterol content and increase in the content of unsaturated fatty acid moieties in the lipid bilayers, augmented the susceptibility of the liposomes to the mercurial compounds. Inorganic Hg and methylmercury disrupted the lipid membrane to essentially the same extent. The influence on the permeability seems to be specific for Hg compounds. The significant increase in the permeability of some liposomal preparation noted even at the mercurial concentration of 10-7 M suggests that lipids in biomembranes may be one of the primary targets of these toxic substances.
