Insights from experimental studies into allodynia and its treatment.
Insights from experimental studies into allodynia and its treatment.
复制标题
DOI：
10.1007/s11916-006-0050-y
复制
发表时间：
2006-06-01
影响因子：
3.7
通讯作者：
Oshinsky, Michael L
中科院分区：
文献类型：
--
作者：
Oshinsky, Michael L
偏头痛是一种常见疾病，通常伴有皮肤异常性疼痛。在偏头痛动物模型中，头部皮肤异常性疼痛与三叉神经尾核神经元的敏化有关。此外，曲坦类药物对伴有异常性疼痛的偏头痛难以进行急性治疗。了解异常性疼痛的机制、预防其发展并寻找有效的治疗方法已成为头痛研究的首要任务。本文综述了头痛发病机制和异常性疼痛产生的最新研究进展。我们讨论神经系统中参与产生和维持头痛和异常性疼痛的区域。我们还讨论了基于翻译研究的偏头痛治疗的最新进展。
Migraine is a common disorder that often is accompanied by cutaneous allodynia. Cutaneous allodynia on the head has been linked to sensitization of neurons in the trigeminal nucleus caudalis in animal models of migraine. In addition, migraine with allodynia is refractory to acute treatment with triptans. Understanding the mechanisms of allodynia, preventing its development, and finding effective treatments have become a priority in headache research. This paper reviews recent research on the pathogenesis of headache and the generation of allodynia. We discuss the regions of the nervous system that are involved in generating and maintaining headache pain and allodynia. We also discuss recent advances in the treatment of migraine based on translation research.