Perfluorinated chemicals in relation to other persistent organic pollutants in human blood
Perfluorinated chemicals in relation to other persistent organic pollutants in human blood
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DOI：
10.1016/j.chemosphere.2005.11.040
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发表时间：
2006-08-01
期刊：
影响因子：
8.8
通讯作者：
Lindstrom, Gunilla
中科院分区：
文献类型：
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作者：
Karrman, Anna;van Bavel, Bert;Lindstrom, Gunilla
为了评估一些全氟化化学品(PFC)的血液水平，并将其与传统持久性有机污染物(POPs)的当前水平进行比较，对瑞典的全血样本进行了12种PFC、37种多氯联苯(PCBS)、对，对‘-二氯二苯基-二氯乙烯(DDE)、六氯苯(HCB)、6种氯丹和3种多溴联苯醚(PBDEs)的分析。在全血基础上，全氟碳化物总和的中位浓度是多氯联苯和p，p‘-DDE总和的20-50倍，是六氯苯、氯丹和多溴二苯醚总和的300-450倍。对全氟化碳和亲脂性持久性有机污染物的人体总量的估计表明，人体负荷相似。虽然将多氯联苯和多溴二苯醚等的水平归一化为血液中的脂肪含量，但对血液中的全氟化碳没有这样的一般程序。因此，我们研究了一些全氟化合物在全血和血浆中的分布。血浆/全血比值在1.1~1.4之间的四种全氟烷基酸的血浆浓度高于全血浓度，而全氟辛烷磺胺(PFOSA)的血浆浓度明显低于全血浓度(0.2)。这表明，在比较血浆和全血中测定的PFC水平时应谨慎。我们还得出结论，瑞典居民接触大量全氟化碳的程度与美国、日本、哥伦比亚和其他几个目前可获得数据的国家相同。(C)2005爱思唯尔有限公司。保留所有权利。
In order to evaluate blood levels of some perfluorinated chemicals (PFCs) and compare them to current levels of classical persistent organic pollutants (POPs) whole blood samples from Sweden were analyzed with respect to 12 PFCs, 37 polychlorinated biphenyls (PCBs), p,p'-dichlorodiphenyl-dichloroethylene (DDE), hexachlorobenzene (HCB), six chlordanes and three polybrominated diphenyl ethers (PBDEs). The median concentration, on whole blood basis, of the sum of PFCs was 20-50 times higher compared to the sum of PCBs and p,p'-DDE, 300-450 times higher than HCB, sum of chlordanes and sum of PBDEs. Estimations of the total body amount of PFCs and lipophilic POPs point at similar body burdens. While levels of for example PCBs and PBDEs are normalized to the lipid content of blood, there is no such general procedure for PFCs in blood. The distributions of a number of perfluorinated compounds between whole blood and plasma were therefore studied. Plasma concentrations were higher than whole blood concentrations for four perfluoroalkylated acids with plasma/whole blood ratios between 1.1 and 1.4, whereas the ratio for perflurooctanesulfonamide (PFOSA) was considerably lower (0.2). This suggests that the comparison of levels of PFCs determined in plasma with levels determined in whole blood should be made with caution. We also conclude that Swedish residents are exposed to a large number of PFCs to the same extent as in USA, Japan, Colombia and the few other countries from which data is available today. (c) 2005 Elsevier Ltd. All rights reserved.