ASSOCIATION OF INFECTION CAUSED BY PSEUDOMONAS-AERUGINOSA SEROTYPE-O11 WITH INTRAVENOUS ABUSE OF PENTAZOCINE MIXED WITH TRIPELENNAMINE
ASSOCIATION OF INFECTION CAUSED BY PSEUDOMONAS-AERUGINOSA SEROTYPE-O11 WITH INTRAVENOUS ABUSE OF PENTAZOCINE MIXED WITH TRIPELENNAMINE
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DOI：
10.1128/jcm.20.4.758-762.1984
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发表时间：
1984-01-01
影响因子：
9.4
通讯作者：
KABINS, SA
中科院分区：
文献类型：
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作者：
LEVIN, MH;WEINSTEIN, RA;KABINS, SA
从1979年7月至1983年6月，40名静脉注射吸毒者中有25名全身感染的病原体为铜绿假单胞菌;到1982年，铜绿假单胞菌已取代金黄色葡萄球菌成为最常见的病原体。在25名感染铜绿假单胞菌的成瘾者中，至少有21人滥用喷他佐辛与曲哌那明（通常称为T's和blues）的混合物，而在15名感染其他病原体的成瘾者中，有6人滥用喷他佐辛（P = 0.006）。在25株铜绿假单胞菌分离株中，23株为血清型O 11。 用绿脓菌素和电泳酶分型，以及对重金属和抗生素的敏感性，测定了22株O 11血清型吸毒者和非吸毒者对照菌株的表型。25个菌株从成瘾者，20是相同的或不同的只有1个标记，22个非成瘾者血清型O 11菌株分布在17个不同的表型模式。铜绿假单胞菌的出现是成瘾者深部感染的主要原因，这可能是在制备喷他佐辛和tripelennemine进行自我注射时污染了他们的随身用品的结果。成瘾者分离株之间的表型相似性可能反映了从相关环境来源获得和某些血清型O 11菌株在药物制备中存活或具有侵入性的不寻常能力。
From July 1979-June 1983, 25 of 40 i.v. drug addicts with systemic infections had P. aeruginosa as the etiological agent; by 1982, P. 4aeruginosa had replaced Staphylococcus aureus as the most common pathogen. At least 21 of the 25 addicts with P. aeruginosa infection abused pentazocine mixed with tripelennamine (commonly known as T''s and blues) compared with 6 of 15 addicts infected with other pathogens (P = 0.006). Of the 25 P. aeruginosa isolates, 23 were of serotype O11. Phenotypic patterns in isolates from addicts and in 22 serotype O11 control isolates from nonaddicts were determined by pyocin and electrophoretic enzyme typing, and by susceptibility to heavy metals and antibiotics. Of 25 isolates from addicts, 20 were identical or differed by only 1 marker; the 22 nonaddict serotype O11 isolates were distributed among 17 distinct phenotypic patterns. The emergence of P. aeruginosa as the major cause of deep infection in addicts may be a consequence of contamination of their paraphernalia during preparation of pentazocine and tripelennemine for self-injection. The phenotypic similarity among isolates from addicts may reflect acquisition from related environmental sources and an unusual ability of certain serotype O11 strains to survive preparation of the drugs or to be invasive.