Emerging roles of the complement system in host-pathogen interactions.
Emerging roles of the complement system in host-pathogen interactions.
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补体系统在宿主-病原体相互作用中的新作用。
DOI：
10.1016/j.tim.2021.09.002
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发表时间：
2022-04
影响因子：
15.9
通讯作者：
Kulkarni HS
中科院分区：
文献类型：
--
作者：
Sahu SK;Kulkarni DH;Ozanturk AN;Ma L;Kulkarni HS
The complement system has historically been entertained as a fluid-phase, hepatically-derived system, which protects the intravascular space from encapsulated bacteria. However, there has been an increasing appreciation for its role in protection against non-encapsulated pathogens. Specifically, we have an improved understanding of how pathogens are recognized by specific complement proteins, as well as how they trigger and evade them. Additionally, we have an improved understanding of locally-derived complement proteins, many of which promote host defense. Moreover, intracellular complement proteins have been identified that facilitate local protection and barrier function despite pathogen invasion. Our review aims to summarize these advances in the field, as well as provide an insight into the pathophysiological changes occurring when the system is dysregulated in infection.
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DOI：
10.1084/jem.20150282
发表时间：
2016-09-19
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Chorny A;Casas-Recasens S;Sintes J;Shan M;Polentarutti N;García-Escudero R;Walland AC;Yeiser JR;Cassis L;Carrillo J;Puga I;Cunha C;Bastos H;Rodrigues F;Lacerda JF;Morais A;Dieguez-Gonzalez R;Heeger PS;Salvatori G;Carvalho A;Garcia-Sastre A;Blander JM;Mantovani A;Garlanda C;Cerutti A
通讯作者：
Cerutti A
影响因子：
7.3
作者：
Ali YM;Ferrari M;Lynch NJ;Yaseen S;Dudler T;Gragerov S;Demopulos G;Heeney JL;Schwaeble WJ
通讯作者：
Schwaeble WJ
影响因子：
7.3
作者：
El Sissy, Carine;Rosain, Jeremie;Fremeaux-Bacchi, Veronique
通讯作者：
Fremeaux-Bacchi, Veronique
T 辅助细胞 1 免疫需要 CD4⁺ T 细胞中补体驱动的 NLRP3 炎性体活性。
DOI：
10.1126/science.aad1210
发表时间：
2016-06-17
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Arbore G;West EE;Spolski R;Robertson AAB;Klos A;Rheinheimer C;Dutow P;Woodruff TM;Yu ZX;O'Neill LA;Coll RC;Sher A;Leonard WJ;Köhl J;Monk P;Cooper MA;Arno M;Afzali B;Lachmann HJ;Cope AP;Mayer-Barber KD;Kemper C
通讯作者：
Kemper C
影响因子：
3.1
作者：
Brock, Susan R.;Parmely, Michael J.
通讯作者：
Parmely, Michael J.