The usefulness of monomeric periostin as a biomarker for idiopathic pulmonary fibrosis.
The usefulness of monomeric periostin as a biomarker for idiopathic pulmonary fibrosis.
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DOI：
10.1371/journal.pone.0174547
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发表时间：
2017
期刊：
影响因子：
3.7
通讯作者：
Consortium for Development of Diagnostics for Pulmonary Fibrosis Patients (CoDD-PF)
中科院分区：
文献类型：
--
作者：
Ohta S;Okamoto M;Fujimoto K;Sakamoto N;Takahashi K;Yamamoto H;Kushima H;Ishii H;Akasaka K;Ono J;Kamei A;Azuma Y;Matsumoto H;Yamaguchi Y;Aihara M;Johkoh T;Kawaguchi A;Ichiki M;Sagara H;Kadota JI;Hanaoka M;Hayashi SI;Kohno S;Hoshino T;Izuhara K;Consortium for Development of Diagnostics for Pulmonary Fibrosis Patients (CoDD-PF)
特发性肺纤维化（IPF）的自然病程是可变的。预测IPF的疾病进展和生存期对于治疗非常重要。我们先前证明血清骨膜蛋白有可能成为IPF的预后生物标志物。我们的目的是在一项多中心研究中使用单体骨膜蛋白来评价其诊断IPF和预测其进展的疗效。为此，我们开发了一种新的骨膜蛋白试剂盒，仅检测单体骨膜蛋白。受试者包括一项多中心队列研究中的60例IPF患者。我们应用单体骨膜蛋白、通过常规试剂盒检测的总骨膜蛋白和常规生物标志物KL-6、SP-D和LDH来诊断IPF，并通过%VC和% DL，CO的短期变化来预测其短期进展。此外，我们将IPF中单体骨膜蛋白与总骨膜蛋白的分数比与其他高骨膜蛋白疾病中的分数比进行了比较：特应性皮炎、系统性硬皮病和哮喘。与KL-6和SP-D相比，单体骨膜蛋白显示出最大的鉴别IPF的能力。单体骨膜蛋白和总骨膜蛋白均与%VC和% DL，CO的下降密切相关。将IPF患者聚类为高骨膜蛋白组和低骨膜蛋白组证明可用于预测IPF的短期进展。此外，IPF中单体骨膜蛋白的相对比例高于其他高骨膜蛋白疾病。测量单体骨膜蛋白有助于诊断IPF并预测其短期进展。此外，与其他高骨膜蛋白疾病相比，IPF中单体骨膜蛋白与总骨膜蛋白的比率升高。
The natural course of idiopathic pulmonary fibrosis (IPF) is variable. Predicting disease progression and survival in IPF is important for treatment. We previously demonstrated that serum periostin has the potential to be a prognostic biomarker for IPF. Our aim was to use monomeric periostin in a multicenter study to evaluate its efficacy in diagnosing IPF and predicting its progression. To do so, we developed a new periostin kit to detect only monomeric periostin. The subjects consisted of 60 IPF patients in a multicenter cohort study. We applied monomeric periostin, total periostin detected by a conventional kit, and the conventional biomarkers—KL-6, SP-D, and LDH—to diagnose IPF and to predict its short-term progression as estimated by short-term changes of %VC and % DL, CO. Moreover, we compared the fraction ratios of monomeric periostin to total periostin in IPF with those in other periostin-high diseases: atopic dermatitis, systemic scleroderma, and asthma. Monomeric periostin showed the greatest ability to identify IPF comparable with KL-6 and SP-D. Both monomeric and total periostin were well correlated with the decline of %VC and % DL, CO. Clustering of IPF patients into high and low periostin groups proved useful for predicting the short-term progression of IPF. Moreover, the relative ratio of monomeric periostin was higher in IPF than in other periostin-high diseases. Measuring monomeric periostin is useful for diagnosing IPF and predicting its short-term progression. Moreover, the ratio of monomeric periostin to total periostin is elevated in IPF compared to other periostin-high diseases.