BOLD and CBV-weighted functional magnetic resonance imaging of the rat somatosensory system
BOLD and CBV-weighted functional magnetic resonance imaging of the rat somatosensory system
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DOI：
10.1002/mrm.20744
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发表时间：
2006-02-01
影响因子：
3.3
通讯作者：
Koretsky, AP
中科院分区：
文献类型：
--
作者：
Keilholz, SD;Silva, AC;Koretsky, AP
使用多层自旋回波EPI序列获得整个大鼠大脑的功能性MR图像，并在11.7 T下进行血氧水平依赖性（BOLD）和脑血容量（CBV）对比。通过将每个图像扭曲到Paxinos大鼠脑图谱并标记激活区域的范围来创建激活发生率的地图。BOLD和CBV的发生率图相似，但BOLD图像中引流静脉的激活比CBV图像中更突出。在BOLD图像中观察到沿着表面的小脑激活，但在CBV图像中在更深的区域。这两种效应都可以通过在CBV fMRI中施用ferumoxtran-10造影剂后EPI图像中的信号丢失和失真增加来解释。还创建了10、20和30 mg Fe/kg剂量ferumoxtran-10的CBV加权发病率图。刺激期间的平均百分比变化幅度从10 mg Fe/kg剂量的4.9%增加到30 mg Fe/kg剂量的8.7%。激活的发生率遵循类似的趋势。
A multislice spin echo EPI sequence was used to obtain functional MR images of the entire rat brain with blood oxygenation level dependent (BOLD) and cerebral blood volume (CBV) contrast at 11.7 T. Maps of activation incidence were created by warping each image to the Paxinos rat brain atlas and marking the extent of the activated area. Incidence maps for BOLD and CBV were similar, but activation in draining veins was more prominent in the BOLD images than in the CBV images. Cerebellar activation was observed along the surface in BOLD images, but in deeper regions in the CBV images. Both effects may be explained by increased signal dropout and distortion in the EPI images after administration of the ferumoxtran-10 contrast agent for CBV fMRI. CBV-weighted incidence maps were also created for 10, 20, and 30 mg Fe/kg doses of ferumoxtran-10. The magnitude of the average percentage change during stimulation increased from 4.9% with the 10 mg Fe/kg dose to 8.7% with the 30-mg Fe/kg dose. Incidence of activation followed a similar trend.