Differential role of monocyte subsets in atherosclerosis
Differential role of monocyte subsets in atherosclerosis
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DOI：
10.1160/th11-07-0500
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发表时间：
2011-11-01
影响因子：
6.7
通讯作者：
Weber, Christian
中科院分区：
文献类型：
--
作者：
Hristov, Mihail;Weber, Christian
内皮功能障碍和动脉壁炎症持续推动动脉粥样硬化的发展。最近出现了有关不同单核细胞亚群依次参与该疾病病理学的详细信息。本综述集中于小鼠和男性的主要单核细胞亚群，并特别讨论了它们在原发性动脉粥样硬化期间的表型、功能和募集，以及它们对继发于斑块破裂的血管生成和组织再生的贡献。
Endothelial dysfunction and inflammation of the arterial wall continuously drive the development of atherosclerosis. Details regarding the sequential involvement of different monocyte subsets in the pathology of this disease have recently emerged. This review concentrates on major monocyte subpopulations in mouse and men and specifically addresses their phenotype, function and recruitment during primary atherosclerosis as well as their contribution to angiogenesis and tissue regeneration secondary to plaque rupture.