Direct Asymmetric Vinylogous and Bisvinylogous Mannich-Type Reaction Catalyzed by a Copper(I) Complex.
Direct Asymmetric Vinylogous and Bisvinylogous Mannich-Type Reaction Catalyzed by a Copper(I) Complex.
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DOI：
10.1021/jacs.6b13042
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发表时间：
2017-02
影响因子：
15
通讯作者：
Hai‐Jun Zhang;Chang-Yun Shi;Feng Zhong;L. Yin
中科院分区：
文献类型：
--
作者：
Hai‐Jun Zhang;Chang-Yun Shi;Feng Zhong;L. Yin
直接催化的不对称乙烯-曼尼希型反应具有高的产率和良好的区域、非对映和对映选择性。控制区域选择性的关键是体积大的N-酰基吡唑和体积大的双膦配体的组合。通过改变配体，将催化体系扩展为双乙烯Mannich反应。通过几次转化证明了葡萄糖类产品的综合用途。
A direct catalytic asymmetric vinylogous Mannich-type reaction has been disclosed in good yield, excellent regio-, diastereo- and enantioselectivity. The key to control the regioselectivity is the combination of a bulky N-acylpyrazole and a bulky bisphosphine ligand. The catalytic system was extended to a bisvinylogous Mannich-type reaction by changing the ligand. The synthetic utility of the vinylogous products was demonstrated by several transformations.