Mild depressive symptoms are associated with amplified and prolonged inflammatory responses after influenza virus vaccination in older adults
Mild depressive symptoms are associated with amplified and prolonged inflammatory responses after influenza virus vaccination in older adults
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DOI：
10.1001/archpsyc.60.10.1009
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发表时间：
2003-10-01
影响因子：
--
通讯作者：
Kiecolt-Glaser, JK
中科院分区：
文献类型：
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作者：
Glaser, R;Robles, TF;Kiecolt-Glaser, JK
背景资料：抑郁症与促炎细胞因子的产生增加有关，这些细胞因子会影响一系列与衰老相关的疾病，包括心血管疾病、骨质疏松症、关节炎、2型糖尿病、某些癌症、牙周病、虚弱和功能衰退。在这项前瞻性社区研究中，我们评估了流感病毒疫苗接种后抑郁症状与炎症反应变化之间的关系。为了研究免疫激发后血浆中白细胞介素6（IL 6）水平的动态变化，我们采集了119名老年人的血液样本（平均年龄，71.21 ± 8.68岁[SD]）。贝克抑郁量表的简短形式，在这些相同的时间完成，提供了抑郁symptoms.Results的信息：在这个样本中的抑郁症状的数量是低的平均接种疫苗前（平均标准差的症状数，3.07 +/- 3.09），并没有显着变化后接种疫苗。有更多抑郁症状的参与者在接种疫苗前后的IL-6水平高于那些报告症状较少的参与者;此外，报告抑郁症状较多的个体在2周后血浆IL-6水平也有所增加，而报告症状较少或没有症状的个体IL-6水平变化不大。即使是少量的抑郁症状也可能使老年人的炎症反应系统敏感，并在感染和其他免疫挑战后产生放大和延长的炎症反应。持续和/或放大的炎症反应可能会加速一系列与年龄相关的疾病。
Background: Depression is associated with enhanced production of proinflammatory cytokines that influence a spectrum of conditions associated with aging, including cardiovascular disease, osteoporosis, arthritis, type 2 diabetes mellitus, certain cancers, periodontal disease, frailty, and functional decline. In this prospective community study, we assessed the relationship between depressive symptoms and changes in inflammatory response after an influenza virus vaccination.Methods: To study the dynamics of interleukin (IL) 6 levels in plasma in response to an immunological challenge, we obtained blood samples in 119 older adults (mean age, 71.21 +/- 8.68 years [SD]) immediately before an annual influenza vaccination and again 2 weeks later. The short form of the Beck Depression Inventory, completed at these same times, provided information on depressive symptoms.Results: The number of depressive symptoms in this sample was low on average before vaccination (mean SD number of symptoms, 3.07 +/- 3.09) and did not change significantly after vaccination. Participants with more depressive symptoms had higher levels of IL-6 before and after vaccination than did those who reported fewer symptoms; moreover, individuals reporting more depressive symptoms also showed an increase in plasma IL-6 levels 2 weeks later, while there was little change in IL-6 levels among those reporting few or no symptoms.Conclusions: Even a modest number of depressive symptoms may sensitize the inflammatory response system in older adults and produce amplified and prolonged inflammatory responses after infection and other immunological challenges. Sustained and/or amplified inflammatory responses could accelerate a range of age-related diseases.