Interrelationship between family history of alcoholism and generational status in the prediction of alcohol dependence in US Hispanics.
Interrelationship between family history of alcoholism and generational status in the prediction of alcohol dependence in US Hispanics.
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DOI：
10.1017/s0033291716002105
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发表时间：
2017-01
影响因子：
6.9
通讯作者：
Kendler KS
中科院分区：
文献类型：
--
作者：
Chartier KG;Thomas NS;Kendler KS
酗酒家族史和移民相关因素（如美国与外国出生）都增加了西班牙裔美国人发生酒精使用障碍的风险。在这项研究中，我们整合了这两条研究线，以检验在美国，家族性酒精中毒和酒精依赖之间的关系是否会随着后代的变化而变化。数据来自第一波和第二波全国酒精及相关疾病流行病学调查（NESARC）。受试者自认为西班牙裔（N = 4122; N = 1784第一代，N = 1169第二代，N = 1169第三代或更晚），并报告在一年内饮用12杯或更多饮料。在一级和二级亲属中评估了酗酒家族史。预测酒精依赖症状数量的分析采用路径模型。酒精依赖症状与较强的酗酒家族史和较晚的代际状况有关。家族性酗酒与代际状态之间存在显著的交互作用；在美国，家族性酒精中毒与酒精依赖症状的关系随着世代的增加而显著增加，女性比男性更明显。文化适应部分介导了家族酒精中毒和代际地位对酒精依赖的相互作用，尽管不是预期的方向。在预测美国西班牙裔饮酒者的酒精依赖症状时，家族性酒精中毒与代际状态相互作用。这种关系表明，酗酒的遗传性受到更高层次的环境因素的影响，其特征可能是社会对饮酒限制的放松。
Both a family history of alcoholism and migration-related factors like U.S. versus foreign nativity increase the risk for developing alcohol use disorders in Hispanic Americans. For this study, we integrated these two lines of research to test whether the relationship between familial alcoholism and alcohol dependence changes with successive generations in the U.S. Data were from the wave 1 and wave 2 National Epidemiologic Survey on Alcohol and Related Conditions (NESARC). Subjects self-identified Hispanic ethnicity (N = 4,122; n = 1,784 first, n = 1,169 second, and n = 1,169 third or later generation) and reported ever consuming 12 or more drinks in a one-year period. A family history of alcoholism was assessed in first and second degree relatives. Analyses predicting the number of alcohol dependence symptoms were path models. Alcohol dependence symptoms were associated with a stronger family history of alcoholism and later generational status. There was a significant interaction effect between familial alcoholism and generational status; the relationship of familial alcoholism with alcohol dependence symptoms increased significantly with successive generations in the U.S., more strongly in women than men. Acculturation partially mediated the interaction effect between familial alcoholism and generational status on alcohol dependence, although not in the expected direction. Familial alcoholism interacted with generational status in predicting alcohol dependence symptoms in U.S. Hispanic drinkers. This relationship suggests that heritability for alcoholism is influenced by a higher order environmental factor, likely characterized by a relaxing of social restrictions on drinking.