Intracellular CICR -associated pharmacological mechanism of action of antiepileptic drugs
Intracellular CICR -associated pharmacological mechanism of action of antiepileptic drugs
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细胞内 CICR 相关抗癫痫药物的药理作用机制
DOI：
10.3805/eands.3.154
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发表时间：
2010
影响因子：
--
通讯作者：
S. Kaneko
中科院分区：
文献类型：
--
作者：
G. Zhu;M. Okada;S. Yoshida;S. Kaneko
卡马西平（CBZ）和唑尼沙胺（ZNS）是具有多种作用机制的抗癫痫药物（AEDs），包括抑制电压依赖性钠和钙通道，增强GABA能神经传递介导的抑制事件，以及阻断脑中的谷氨酸能神经传递。近年来，细胞内信号通路被认为是抗癫痫药物的新靶点。特别地，我们研究了钙动员在癫痫发病机制和AEDs的药理学机制中的功能重要性，钙动员包括通过钙通道的内流和通过兰尼碱受体（RyR）和肌醇三磷酸受体（IP3R）敏感的细胞内钙诱导的钙释放系统（CICRs）的输出。在这篇综述中，我们讨论了CBZ和ZNS对与RyR敏感的CICR相关的神经递质胞吐的作用。对AEDs作用机制的进一步研究可能有助于了解AEDs治疗癫痫疾病的临床益处。
Carbamazepine (CBZ) and zonisamide (ZNS) are antiepileptic drugs (AEDs) with multiple mechanisms of action, including inhibition of voltage-dependent sodium and calcium channels, enhancement of inhibitory events mediated by GABAergic neurotransmission, and blockade of the glutamatergic neurotransmission in the brain. Recently, the intracellular signaling pathways have been implicated as the new targets of AEDs. Especially, we have investigated the functional importance of Ca2+ mobilization, composed of influx through Ca2+ channels and output through ryanodine receptor (RyR)- and inositol-triphosphate receptor (IP3R)-sensitive intracellular Ca2+-induced Ca2+ releasing systems (CICRs), in the pathogenesis of epilepsy and the pharmacological mechanism of AEDs. In this review, we discuss the actions of CBZ and ZNS on neurotransmitter exocytosis associated with RyR-sensitive CICR. Further studies on the mechanisms of action of AEDs may help to understand the clinical benefits of AEDs in the treatment of epilepsy disorders.
影响因子：
4
作者：
Pal, S;Sun, D;DeLorenzo, RJ
通讯作者：
DeLorenzo, RJ
开放标签辅助唑尼沙胺治疗双相情感障碍：一项前瞻性试验。
DOI：
10.4088/jcp.v66n0512
发表时间：
2005
期刊：
The Journal of clinical psychiatry
影响因子：
--
作者：
McElroy,SusanL;Suppes,Trisha;KeckJr,PaulE;Black,David;Frye,MarkA;Altshuler,LoriL;Nolen,WillemA;Kupka,RalphW;Leverich,GabrieleS;Walden,Jorg;Grunze,Heinz;Post,RobertM
通讯作者：
Post,RobertM