Prenylflavonol, acylated flavonol glycosides and related compounds from Epimedium sagittatum
Prenylflavonol, acylated flavonol glycosides and related compounds from Epimedium sagittatum
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DOI：
10.1016/j.phytochem.2007.05.035
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发表时间：
2007-10-01
期刊：
影响因子：
3.8
通讯作者：
Lin, Lie-Chwen
中科院分区：
文献类型：
--
作者：
Wang, Guei-Jane;Tsai, Tung-Hu;Lin, Lie-Chwen
对淫羊藿地上部分的正丁醇提取物进行化学检查，分离出三种异戊二烯化黄酮醇糖苷 sagittasine A-C、两种酰化黄酮醇糖苷山奈酚-3-O-(2''-E-p-香豆酰基，4''-Z-p-香豆酰基)-α-L-吡喃鼠李糖苷和 山奈酚-3-O-(3''-Z-对香豆酰基，4''-E-α-香豆酰基)-α-L-吡喃鼠李糖苷，以及已知的类黄酮、黄酮木脂素、2-苯氧基色酮、木脂素和芳香酸衍生物。首次在该植物中鉴定出黄酮木脂素。使用器官浴装置中预先收缩的大鼠主动脉环测试了箭矢状桉正丁醇提取物和 13 种分离化合物的血管舒张特性。结果表明，箭矢正丁醇提取物产生部分内皮一氧化氮依赖性血管舒张作用，EC50 为 0.16 +/- 0.03 mg/ml。然而，所测试的13种化合物仅产生轻度或中度的舒张作用，并且单独不具有显着的血管舒张作用。 (C) 2007 Elsevier Ltd. 保留所有权利。
Chemical examination of the n-BuOH extract from the aerial parts of Epimedium sagittatum led to isolation of three prenylated flavonol glycosides sagittasine A-C, two acylated flavonol glycosides kaempferol-3-O-(2 ''-E-p-coumaroyl,4 ''-Z-p-coumaroyl)-alpha-L-rhamnopyranoside and kaempferol-3-O-(3 ''-Z-p-coumaroyl,4 ''-E-alpha-coumaroyl)-alpha-L-rhamnopyranoside, together with known flavonoids, flavonolignans, 2-phenoxychromones, a lignan, and aromatic acid derivatives. Flavonolignans were identified for the first time in this plant. The vasorelaxing properties of the n-BuOH extract of E. sagittatum and 13 isolated compounds were tested using pre-contracted rat aorta rings in an organ bath apparatus. The results indicated that the n-BuOH extract of E sagittatum produced a partial endothelial nitric oxide-dependent vasorelaxation, with EC50 of 0.16 +/- 0.03 mg/ml. However, the 13 compounds tested, generated only a mild or moderate relaxation, and did not possess significant vasorelaxing effect individually. (C) 2007 Elsevier Ltd. All rights reserved.