Cardioprotective Effects and Mechanisms of Saponins on Cardiovascular Disease
Cardioprotective Effects and Mechanisms of Saponins on Cardiovascular Disease
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DOI：
10.1177/1934578x221147404
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发表时间：
2022-12
影响因子：
1.8
通讯作者：
Xin Ma;Jun Lu;Xuerong Gu;Yinnong Jia;Baochun Shen;Yang Weiming;Guangsheng Du;Chang-Bo Zheng
中科院分区：
文献类型：
--
作者：
Xin Ma;Jun Lu;Xuerong Gu;Yinnong Jia;Baochun Shen;Yang Weiming;Guangsheng Du;Chang-Bo Zheng
心血管疾病（CVD）是发病率和死亡率的主要原因，是世界范围内最普遍的健康问题之一，迫切需要有效的预防和治疗策略。在这方面，越来越多的研究表明，天然药物具有抗高血压、抗动脉粥样硬化和心脏保护活性，并且许多天然药物被广泛用于治疗CVD及其表现，如心肌梗死、外周血管疾病和冠心病。天然药物由于其疗效和安全性而在治疗CVD方面具有显着优势。皂苷类化合物是一类重要的植物天然产物活性成分，在治疗心血管疾病中具有重要作用。本文综述了皂苷类化合物的心脏保护作用及其作用机制。
Cardiovascular disease (CVD), a leading cause of morbidity and mortality, is among the most prevalent health problems worldwide and effective strategies for its prevention and treatment are urgently required. In this regard, increasing research has demonstrated that natural drugs offer antihypertensive, antiatherosclerotic, and cardioprotective activities, and many are applied widely for the treatment of CVD and its manifestations such as myocardial infarction, peripheral vascular diseases, and coronary heart disease. Natural drugs have significant advantages in the treatment of CVD due to their efficacy and safety profiles. Saponins are an important class of active components of plant natural products and play an important role in the treatment of CVD. This review covers the most up-to-date information on saponins concerning their cardioprotective effects and mechanisms of action.