Central cholinergic involvement in working memory: effects of scopolamine on continuous nonmatching and discrimination performance in the rat.
Central cholinergic involvement in working memory: effects of scopolamine on continuous nonmatching and discrimination performance in the rat.
复制标题
工作记忆中的中枢胆碱能参与：东莨菪碱对大鼠连续不匹配和辨别表现的影响。
作者：
D. Spencer;M. Pontecorvo;G. A. Heise
大鼠被训练到稳定的杠杆按压基线，按可变的试验间间隔，连续不匹配样本程序(CNM)或类似的辨别程序。在三个试验间(保持)时间间隔：2.5、5和10 S中，东莨菪碱降低CNM操作的准确性的程度相似，结果表明该药物不影响工作记忆中依赖时间的保持过程。当CNM任务和辨别任务的操作准确度基线水平相似时(但CNM任务的刺激可区分度更高)，东莨菪碱在这两个程序中的准确率同样降低。通过降低刺激区分度来模拟东莨菪碱对非校正实验CNM成绩的影响；然而，东莨菪碱对CNM校正试验成绩的影响要远远大于刺激区分度的降低。结论：东莨菪碱对工作记忆的影响不仅限于对刺激辨别的可能影响，还可能影响对参考记忆反应规则的提取。
Rats were trained to stable baselines of lever pressing on a variable intertrial interval continuous nonmatching to sample schedule (CNM) or on an analogous discrimination schedule. Scopolamine reduced accuracy of CNM performance to a similar extent over the three intertrial (retention) intervals: 2.5, 5, and 10 s, results indicating that the drug did not affect the time-dependent process of retention in working memory. When baseline levels of performance accuracy were similar in the CNM and discrimination tasks (but stimulus discriminability was greater in the CNM task), scopolamine reduced accuracy equally in the two procedures. Effects of scopolamine on accuracy of noncorrection trial CNM performance were simulated by reducing stimulus discriminability; however, scopolamine disrupted CNM correction trial performance much more than did reductions in stimulus discriminability. It is concluded that scopolamine's effects on working memory are not limited to possible effects on stimulus discrimination: Scopolamine may also affect retrieval of response rules from reference memory.