Inhibition of a Langerhans cell-mediated immune response by treatment modalities useful in psoriasis.
Inhibition of a Langerhans cell-mediated immune response by treatment modalities useful in psoriasis.
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通过适用于牛皮癣的治疗方式抑制朗格汉斯细胞介导的免疫反应。
DOI：
10.1111/1523-1747.ep12537586
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发表时间：
1983
期刊：
影响因子：
--
通讯作者：
Engleman,EG
中科院分区：
文献类型：
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作者：
Morhenn,VB;Orenberg,EK;Kaplan,J;Pfendt,E;Terrell,C;Engleman,EG
银屑病的发病机制和看似不同的治疗方法改变疾病的机制都不清楚。在这项研究中，几种抗银屑病药物进行了测试，其对皮肤细胞淋巴细胞反应（SLR），一种免疫学试验，其中的HLA-DR抗原的朗格汉斯细胞（LC）刺激同种异体淋巴细胞的增殖的影响。每一种测试药物（皮质醇、甲氨蝶呤、高热、蒽林）在治疗剂量水平抑制SLR。相比之下，多种抗生素，抗炎剂，碳酸锂和心得安，两种已知对银屑病无效的药物，未能抑制SLR。最后，我们已经表明，热疗和蒽林治疗是有毒的LC，而他们有很少或没有影响角质形成细胞的活力。这些结果表明，抗银屑病药物可能通过改变或杀死LC来治疗银屑病。
Neither the pathogenesis of psoriasis nor the mechanism whereby seemingly diverse therapies alter the disease is understood. In this study, several antipsoriatic agents were tested for their effects on the skin cell lymphocyte reaction (SLR), an immunologic assay in which HLA-DR antigens on Langerhans cells (LC) stimulate proliferation of allogeneic lymphocytes. Every agent tested (cortisol, methotrexate, hyperthermia, anthralin) inhibited the SLR at therapeutic dose levels. By contrast, a variety of antibiotics, an anti-inflammatory agent, and lithium carbonate and propranolol, two drugs known to be ineffective in psoriasis, failed to inhibit the SLR. Finally, we have shown that hyperthermia and anthralin treatments are toxic for LC whereas they have little or no effect on keratinocyte viability. These results suggest that antipsoriatic agents may act in psoriasis by alteration or killing of LC.